Selected fares from San Diego to San Francisco

Orbitz offers premium discounts on flights from San Diego to San Francisco, so you'll have plenty of money left over for sightseeing and souvenirs.

Flights from San Diego to San Francisco depart from San Diego International Airport, constructed and dedicated in 1928. San Diego International is the world's second busiest single-runway airport, and with over 600 departures and arrivals daily, passengers have plenty of San Diego to San Francisco flights to choose from. The airport is located within three miles of the city center and within fifteen miles of the U.S.-Mexico border. When driving to meet San Diego to San Francisco flights, travelers will access the airport via Interstate Five. Once at the airport, visitors can park in any of the airport's parking lots, which are marked with San Diego-themed graphics to help passengers remember where they parked.

Flights from San Diego to San Francisco arrive at San Francisco International Airport, which is a hub for United Airlines and Virgin America. Upon landing aboard San Diego to San Francisco flights, passengers will be roughly thirteen miles from downtown San Francisco. Those who wish to drive can rent cars at the airport and access the downtown area via Highway 101. San Francisco is an ideal city for walking and bicycling, and its public transportation is fairly extensive, so tourists intending to stay within the city can save money by avoiding rental cars. The BART train and SamTrans buses connect the airport to downtown San Francisco and surrounding areas.

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Save more with San Francisco Flight + Hotel packages

Hotels in San Francisco

See all 426 Hotels in San Francisco
Pier 2620 Hotel Fisherman's Wharf
Pier 2620 Hotel Fisherman's Wharf
2620 Jones Street, San Francisco
3.5 out of 5.0
4.1 out of 5 (125 reviews)

Located in the heart of San Francisco, this hotel is within a 10-minute walk of Ripley's Believe It Or Not Museum, Wax Museum at Fisherman's Wharf, and Ghirardelli ...

$220

$220
Park Central Hotel San Francisco, a Starwood Hotel
Park Central Hotel San Francisco, a Starwood Hotel
50 3rd St, San Francisco
4.0 out of 5.0
4.0 out of 5 (206 reviews)

Located in the heart of the South of Market district (SoMa), Park Central Hotel San Francisco (formerly Westin Market Street) is across from Yerba Buena Gardens ...

$201

$201
Stanford Court San Francisco
Stanford Court San Francisco
905 California Street, San Francisco
4.0 out of 5.0
4.3 out of 5 (236 reviews)

Guests can indulge in high-end shops like Prada and Tiffany & Co at Union Square, 4 blocks away. Chinatown is 5 minutes on foot, and the American Conservatory ...

$219

$219
Hotel Nikko San Francisco
Hotel Nikko San Francisco
222 Mason St, San Francisco
4.0 out of 5.0
4.2 out of 5 (355 reviews)

The Asian-inspired Hotel Nikko San Francisco is located downtown, a 4-minute walk from Union Square and the designer shops of Westfield San Francisco Centre. ...

$199

$199
Hilton San Francisco Union Square
Hilton San Francisco Union Square
333 O'Farrell St., San Francisco
4.0 out of 5.0
3.9 out of 5 (497 reviews)

Iconic, AAA 4-Diamond hotel a few steps from Union Square, Cable Car station, theatre district, BART, Chinatown, SFMOMA, and Moscone Center. Upgraded rooms offer ...

$234

$234
Hotel Whitcomb
Hotel Whitcomb
1231 Market St, San Francisco
3.5 out of 5.0
3.4 out of 5 (455 reviews)

Located in the San Francisco theater district with a BART and MUNI station at its entrance, this downtown hotel is 6 blocks from Union Square and within a mile ...

$219

$219
Serrano Hotel
Serrano Hotel
405 Taylor St, San Francisco
4.0 out of 5.0
4.1 out of 5 (100 reviews)

The Serrano Hotel is steps away from Union Square, perfectly positioned in the Theater District of San Francisco, 2 blocks from the Powell Street cable car.

$183

$183
Clift
Clift
495 Geary St, San Francisco
4.0 out of 5.0
4.6 out of 5 (11 reviews)

Old-world elegance is suffused with modern glamour in this historic San Francisco hotel 2 blocks from Union Square, a half-mile from the Financial District, ...

$229

$229
Parc 55 San Francisco - A Hilton Hotel
Parc 55 San Francisco - A Hilton Hotel
55 Cyril Magnin St, San Francisco
4.0 out of 5.0
4.0 out of 5 (526 reviews)

Just off Market Street, downtown San Francisco's major thoroughfare, this contemporary 32-story hotel is 1 block from San Francisco Centre shops and 3 blocks ...

$234

$234
Handlery Union Square Hotel
Handlery Union Square Hotel
351 Geary St, San Francisco
3.5 out of 5.0
4.1 out of 5 (304 reviews)

A half-block from cable cars, this hotel is 2 blocks from Westfield San Francisco Shopping Centre; the Moscone Center and the San Francisco Museum of Modern ...

$209

$209

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 48 hours. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.