$140 Cheap flight deals from Knoxville (TYS) to James Island (CHS)

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Airfares from $140 One Way, $294 Round Trip from Knoxville to James Island

Prices starting at $294 for return flights and $140 for one-way flights to James Island were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, May 19 - Sat, May 23
TYS
Knoxville
CHS
Charleston
$294 Roundtrip, found 1 day ago
$294
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Tue, May 19 from Knoxville to Charleston, returning Sat, May 23, priced at $294 found 1 day ago
Tue, May 19 - Sat, May 23
TYS
Knoxville
CHS
Charleston
$304 Roundtrip, found 1 day ago
$304
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Tue, May 19 from Knoxville to Charleston, returning Sat, May 23, priced at $304 found 1 day ago
Tue, Jun 16 - Fri, Jun 19
TYS
Knoxville
CHS
Charleston
$308 Roundtrip, found 3 days ago
$308
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Tue, Jun 16 from Knoxville to Charleston, returning Fri, Jun 19, priced at $308 found 3 days ago
Tue, May 19 - Sat, May 23
TYS
Knoxville
CHS
Charleston
$314 Roundtrip, found 1 day ago
$314
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Tue, May 19 from Knoxville to Charleston, returning Sat, May 23, priced at $314 found 1 day ago
Tue, Jun 16 - Fri, Jun 19
TYS
Knoxville
CHS
Charleston
$318 Roundtrip, found 3 days ago
$318
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Tue, Jun 16 from Knoxville to Charleston, returning Fri, Jun 19, priced at $318 found 3 days ago

James Island economy flight packages

Price found within the past 48 hours. Click for updated prices.
OYO Hotel Ridgeland East
2.5-star property

OYO Hotel Ridgeland East

6.2/10 (161 reviews)

May 28 - May 31

3 night stay

Knoxville (TYS) to Charleston (CHS)

American Airlines • Non-stop • Coach

Charleston (CHS) to Knoxville (TYS)

Southwest Airlines • Non-stop • Coach
Price was $566, price is now $507 per person
$507
per person
found 3 hours ago
The whole staff was very friendly and helpful, I will definitely be staying here again Thanks for everything!

Reviewed on Sep 18, 2022

Oasis Inn
2.5-star property

Oasis Inn

7.4/10 Good! (598 reviews)

May 28 - May 31

3 night stay

Knoxville (TYS) to Charleston (CHS)

American Airlines • Non-stop • Coach

Charleston (CHS) to Knoxville (TYS)

Southwest Airlines • Non-stop • Coach
Price was $594, price is now $560 per person
$560
per person
found 3 hours ago
Neal and his family (with adorable young kiddo) own this lovely hotel. They treat you like family. Want extra pillows? They bring them up with a smile in 5-10 minutes. They purchased Oasis 2 years ago. The work they have done is spot on. Great renovation and focus on customer service. Highly recommend putting your money into a stay with this wonderful young family instead of supporting corporate America in the cookie cutter hotels near by. Yes, it isn’t as new. One of the comforters had signs of age (clean, just aging). Yes, the reception area could use better signage and upgrades. However, how often do you get to make a difference in someone’s life AND safe money while doing it? Oasis is the cheapest good hotel in the area so you save money AND get the feel good of knowing that your stay helped support Neal’s family’s dreams. Your stay would help him get closer to buying the new comforters and a few other upgrades that will make this place even better. Say no to supporting huge corporations and yes to a fantastic feel good stay with Neal at the Oasis. Comfy, clean beds/room for super cheap price.

Reviewed on Jul 24, 2023

Beaufort Inn
3.5-star property

Beaufort Inn

9/10 Wonderful! (1,002 reviews)

May 28 - May 31

3 night stay

Knoxville (TYS) to Charleston (CHS)

American Airlines • Non-stop • Coach

Charleston (CHS) to Knoxville (TYS)

Southwest Airlines • Non-stop • Coach
Price was $887, price is now $839 per person
$839
per person
found 3 hours ago
Property was clean, walkable only few steps to a rooms, very good hot breakfast,

Reviewed on Sep 11, 2025

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More About Flying To James Island from Knoxville

Route Information for Flights from Knoxville to James Island

Origin Airport IATA Code
TYS
Destination Airport IATA Code
CHS
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Knoxville to James Island

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Orbitz is your number one source for low fares for Knoxville to James Island flights. Our low price guarantee on domestic and international air tickets give you great savings for a perfect trip to James Island. Need hotels too? You can book them last minute on your mobile phone.

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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.