$119 Cheap flight deals from Panama City (PNS) to Knoxville (TYS)

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This Weekend's Flight Deals from Panama City to Knoxville

This weekend's flight prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Nov 22 - Mon, Nov 24
ECP
Northwest Florida Beaches Intl.
TYS
McGhee Tyson
$419 Roundtrip, found 12 hours ago
$419
Roundtrip
found 12 hours ago
Select Delta flight, departing Sat, Nov 22 from Northwest Florida Beaches Intl. to McGhee Tyson, returning Mon, Nov 24, priced at $419 found 12 hours ago
Sat, Nov 22 - Mon, Nov 24
VPS
Northwest Florida Regional
TYS
McGhee Tyson
$424 Roundtrip, found 12 hours ago
$424
Roundtrip
found 12 hours ago
Select Delta flight, departing Sat, Nov 22 from Northwest Florida Regional to McGhee Tyson, returning Mon, Nov 24, priced at $424 found 12 hours ago

Airfares from $119 One Way, $200 Round Trip from Panama City to Knoxville

Prices starting at $200 for return flights and $119 for one-way flights to Knoxville were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.

Wed, Feb 18 - Thu, Mar 5
PNS
Pensacola
TYS
Knoxville
$200 Roundtrip, found 5 days ago
$200
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Wed, Feb 18 from Pensacola to Knoxville, returning Thu, Mar 5, priced at $200 found 5 days ago
Wed, Feb 11 - Thu, Feb 26
PNS
Pensacola
TYS
Knoxville
$210 Roundtrip, found 5 days ago
$210
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Wed, Feb 11 from Pensacola to Knoxville, returning Thu, Feb 26, priced at $210 found 5 days ago
Wed, Dec 24 - Thu, Jan 8
PNS
Pensacola
TYS
Knoxville
$224 Roundtrip, found 6 days ago
$224
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Wed, Dec 24 from Pensacola to Knoxville, returning Thu, Jan 8, priced at $224 found 6 days ago
Tue, Jan 20 - Tue, Feb 3
VPS
Fort Walton Beach
TYS
Knoxville
$231 Roundtrip, found 5 days ago
$231
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Jan 20 from Fort Walton Beach to Knoxville, returning Tue, Feb 3, priced at $231 found 5 days ago
Sat, Jan 24 - Tue, Feb 3
VPS
Fort Walton Beach
TYS
Knoxville
$232 Roundtrip, found 5 days ago
$232
Roundtrip
found 5 days ago
Select Delta flight, departing Sat, Jan 24 from Fort Walton Beach to Knoxville, returning Tue, Feb 3, priced at $232 found 5 days ago

Knoxville first class flight packages

Price found within the past 48 hours. Click for updated prices.
Brookside Lodge
3.0-star property

Brookside Lodge

8.6/10 Excellent! (2,114 reviews)

Dec 28 - Jan 2

5 night stay

Fort Walton Beach (VPS) to Knoxville (TYS)

American Airlines • Non-stop roundtrip • FirstClass
Price was $1,225, price is now $949 per person
$949
per person
found 1 day ago
A place was a little older than we expected, especially for the price. Nice, easy walk to get pancake breakfast Sunday morning.

Reviewed on Nov 2, 2025

River Edge Inn
2.0-star property

River Edge Inn

8.6/10 Excellent! (1,003 reviews)

Dec 28 - Jan 2

5 night stay

Fort Walton Beach (VPS) to Knoxville (TYS)

American Airlines • Non-stop roundtrip • FirstClass
Price was $1,527, price is now $1,077 per person
$1,077
per person
found 1 day ago
Clean room, great location, friendly staff, nice balcony

Reviewed on Nov 9, 2025

Courtyard by Marriott Gatlinburg Downtown
3.0-star property

Courtyard by Marriott Gatlinburg Downtown

9/10 Wonderful! (1,002 reviews)

Dec 28 - Jan 2

5 night stay

Fort Walton Beach (VPS) to Knoxville (TYS)

American Airlines • Non-stop roundtrip • FirstClass
Price was $1,396, price is now $1,074 per person
$1,074
per person
found 1 day ago
The room was beautiful.

Reviewed on Oct 6, 2025

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More About Flying To Knoxville from Panama City

Route Information for Flights from Panama City to Knoxville

Origin Airport IATA Code
PNS
Destination Airport IATA Code
TYS
Distance
Direct Flight Airlines
Earliest Flight Arrival
Latest Flight Arrival

Panama City to Knoxville

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Frequently asked questions

Are there non-stop flights from Panama City to Knoxville?
Allegiant Air will fly you nonstop from Northwest Florida Regional Airport (VPS) to McGhee Tyson Airport (TYS), which means you won't have to stress about swapping planes or missing your connection on this route.
What is the shortest flight from Panama City to Knoxville?
If conditions are good and there are no delays, you could be stepping off the plane at TYS from Pensacola Airport in only 1 hour and 58 minutes. With such a brief flight time, think about bringing hand luggage only.
What airlines fly from Panama City to Knoxville most frequently?
Allegiant Air is the most frequent flyer along this route. This top-rated carrier operates 8 flights from Destin–Fort Walton Beach Airport to Knoxville Airport every month.
What is the cheapest day of the week to fly?
Consider flying out early in the week to save on your airfare. Orbitz data from 2021 shows that Monday is the cheapest day to depart, followed by Tuesday. Saturday showed the highest average ticket prices likely because many travelers prefer to start their vacation on a weekend.
What is the cheapest month to fly?
We won't keep you guessing, according to Orbitz data from 2021, the cheapest month to fly is February. Perfect for those who need a weekend getaway, or just a break from it all in the shortest month of the year. Be aware that the most expensive time to fly is during the height of summer in July, and in the holiday month of December.*According to flight demand on Orbitz.com from January to December 2021. Savings are subject to change based on departure location, date and destination.

More Destinations

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.