$318 Cheap flight deals from Syracuse (SYR) to Jefferson (DSM)
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Airfares from $318 One Way, $326 Round Trip from Syracuse to Jefferson
Prices starting at $326 for return flights and $318 for one-way flights to Jefferson were the cheapest prices found within the past 7 days, for the period specified. Prices and availability are subject to change. Additional terms apply.
Jefferson economy flight packages
Sonesta Simply Suites Des Moines
Aug 21 - Aug 23
Syracuse (SYR) to Des Moines (DSM)
Reviewed on Jul 1, 2026
TownePlace Suites by Marriott - Des Moines Urbandale
Aug 21 - Aug 23
Syracuse (SYR) to Des Moines (DSM)
Reviewed on Jul 10, 2026
More About Flying To Jefferson from Syracuse
Route Information for Flights from Syracuse to Jefferson
Origin Airport IATA Code | SYR |
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Destination Airport IATA Code | DSM |
Distance | |
Direct Flight Airlines | |
Earliest Flight Arrival | |
Latest Flight Arrival |
Syracuse to Jefferson
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Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 7 days. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.
Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.
Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.