Package deals near Historic Main Street

Save more on your trip when booking your flight + hotel together

Top Historic Main Street vacation deals

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Express & Suites - O'Fallon /Shiloh by IHG
2.5-star property

Holiday Inn Express & Suites - O'Fallon /Shiloh by IHG

8.4/10 Very Good! (541 reviews)

Mar 7 - Mar 9

2 night stay

Denver (DEN) to St. Louis (STL)

Frontier Airlines • Roundtrip • Coach
Price was $295, price is now $240 per person
$240
per person
found 1 day ago
Clean facilities, great staff, good breakfast. Nice experience, I recommend

Reviewed on Jan 1, 2024

Hermann Grain Bins BNB
2.0-star property

Hermann Grain Bins BNB

2/10 (1 review)

Apr 6 - Apr 9

3 night stay

Milwaukee (MKE) to St. Louis (STL)

Southwest Airlines • Coach

St. Louis (STL) to Milwaukee (MKE)

Delta • Coach
Price was $965, price is now $712 per person
$712
per person
found 1 day ago
Spacious 3-Bedroom with King Bed
4.0-star property

Spacious 3-Bedroom with King Bed

Central West End
8.6/10 Excellent! (10 reviews)

Mar 7 - Mar 9

2 night stay

Denver (DEN) to St. Louis (STL)

Frontier Airlines • Roundtrip • Coach
Save 100% on your flight
Price was $759, price is now $596 per person
$596
per person
found 1 day ago
The Wildwood Hotel
3.5-star property

The Wildwood Hotel

9.2/10 Wonderful! (1,600 reviews)

Feb 17 - Feb 19

2 night stay

Boston (BOS) to St. Louis (STL)

American Airlines • Coach

St. Louis (STL) to Boston (BOS)

Southwest Airlines • Coach
Price was $596, price is now $471 per person
$471
per person
found 1 day ago
This hotel was fantastic! Check in was easy with friendly staff, the room was beautiful and well appointed. Breakfast was advertised as a Continental, however they had hot options as well, which was great. Every staff member we saw in the hotel said hi and was friendly. I would definitely stay here again!

Reviewed on Oct 16, 2025

The Mercantile on the Katy Trail
4.5-star property

The Mercantile on the Katy Trail

9.8/10 Exceptional! (28 reviews)

Apr 6 - Apr 9

3 night stay

Milwaukee (MKE) to St. Louis (STL)

Southwest Airlines • Coach

St. Louis (STL) to Milwaukee (MKE)

Delta • Coach
Price was $664, price is now $535 per person
$535
per person
found 1 day ago
This is an amazing stop for anyone riding the Katy (or anyone visiting Hermann). We found it a perfect stop at the end of the long day of riding. It was right off the trail and they made it easy (so we didn't have to go out that day). The communication was great; the place was lovely. We would absolutely stay here anytime I'm visiting this area.

Reviewed on May 26, 2025

Ameristar Casino Resort and Spa
4.5-star property

Ameristar Casino Resort and Spa

8.4/10 Very Good! (1,006 reviews)

Mar 27 - Mar 30

3 night stay

Los Angeles (LAX) to St. Louis (STL)

Southwest Airlines • Coach

St. Louis (STL) to Los Angeles (LAX)

Frontier Airlines • Coach
Price was $782, price is now $638 per person
$638
per person
found 1 day ago
Room was nice. Enjoyed the pool view and spaciousness. Staff was friendly upon arrival and departure.

Reviewed on Dec 2, 2025

Hotel deals near Historic Main Street

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Free Cancellation
Reserve now, pay when you stay
0.89 mi from Historic Main Street
$193 nightly
The price is $226 total per night
$226 total
Jan 19 - Jan 20
Total with taxes and fees
Guests of Ameristar Casino Resort and Spa have access to a full-service spa, a casino, and a 24-hour gym. The 24-hour front desk has multilingual staff ready to assist with luggage storage and concierge services. Other amenities at this luxury hotel include 2 hot tubs, a conference center, and a seasonal outdoor pool.
Pool
Hot Tub
The St. Charles Guest House, lovely historic home, fun for families and groups

The St. Charles Guest House, lovely historic home, fun for families and groups

St. Charles MO
0.11 mi from Historic Main Street
Get rates
This vacation home offers a water park, an arcade/game room, and laundry facilities.
Kitchen
Washer
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

2.5 out of 5
1190 S Main St St. Charles MO
Free Cancellation
0.62 mi from Historic Main Street
$112 nightly
The price is $128 total per night
$128 total
Jan 25 - Jan 26
Total with taxes and fees
Guests staying at Country Inn & Suites by Radisson, St. Charles Historic District enjoy an indoor pool, a gym, and free WiFi in public areas. Free parking is included with your stay. The 24-hour front desk has staff standing by to help with securing valuables, concierge services, and luggage storage. Additional amenities include a library, laundry facilities, and a vending machine.
Pool
Breakfast included
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Book a Historic Main Street vacation package

Stop dreaming and start traveling. If you’ve always wanted to see Historic Main Street, now is the perfect time. Book your getaway to St. Louis with Orbitz and get ready to tick this attraction off your bucket list. Plus when you lock in your package with us, you’ll have plenty of cash leftover to splash out on other amazing St. Louis sights. Because travel is all about investing in experiences, not things!

If you’re hoping to stay close to Historic Main Street, we’ve got you covered. Choose from a great range of hotels not far from this attraction. Roll out of bed, slip on your walking shoes and you’ll be there within moments. What could be more convenient than that? You won’t just be close to all the action — you’ll save money on transportation, and a hot shower and cozy bed will be within reach after a big day of exploring. Now that’s what we call a stress- free, full-of-fun getaway.

Orbitz has your ticket to a rewarding Historic Main Street vacation. Book your St. Louis package with us and you’ll be able to access Orbitz Rewards. Earn Orbucks when you reserve your flights, hotels and activities with Orbitz and redeem them at over 385,000 hotels worldwide. $1 Orbuck = $1 off your next hotel. Join, earn, redeem — just like that! When you join Orbitz Rewards, you’ll also instantly unlock exclusive deals and save on thousands of properties with Insider Pricing.

We believe the best reward that you can give to yourself or others is the gift of travel. So, don’t put off exploring Historic Main Street any longer. Save a bundle and book your St. Louis escape with Orbitz today.

^Savings based on all package bookings with Flight + Hotel made on Orbitz.com from 2019-04-01 - 2020-03-31 as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.