Important: This destination may have COVID-19 travel restrictions in place, including specific restrictions for lodging. Check any national, local, and health advisories for this destination before you book.

Book Cayo Largo Vacations

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Car Rentals in Cayo Largo

You'll relish every second you spend in intriguing Cayo Largo. The travel specialists at Orbitz can help you get started by linking up amazing-value hotels and airfares. How do savings of up to $369^ sound? Simply choose your preferred airfares, hotels, experiences and rental cars and you'll have some extra change bouncing around in your pockets! On top of that, you'll be excited to hear that you can pick from 500 airline partners and more than 500,000 accommodations across the globe. With unlimited options to pick from, our packages will help you design that vacation you've long dreamed about. Ready to cross Cayo Largo off your world map?

Hi there, globetrotter. We know you want to get the most out of your getaway, so why not check out car rentals in Cayo Largo? Book with Orbitz and get your adventure on the road today! Unfortunately, there aren't any car rental outlets next to Vilo Acuna Airport. You'll have to hail a cab or investigate public transport if you want to journey the 5 miles into town.

Nearest Airports to Cayo Largo

Airports. They can be a bit of a hassle, but traveling would definitely be a lot harder without them! The closest to Cayo Largo is Vilo Acuna Airport (CYO). It's located 5 miles from the downtown area.

Popular Places to Visit Near Cayo Largo

If you're keen to venture a little further afield, you could check out Playa Giron, which is 40 miles away. Museum of the Intervention is just one of the interesting things to do here. Los Peces Caves is another place to visit while you are here.

No Cancellation Fees

Dusted off your passport, booked your big adventure but now you can't go? No need to worry — we make canceling simple and straightforward by not requesting a fee.^ Act promptly and your selected hotel and airline might do the same!

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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