Book Cayo Largo Vacations

You'll relish every second you spend in intriguing Cayo Largo. The travel specialists at Orbitz can help you get started by linking up amazing-value hotels and airfares.

How do savings of up to $369^ sound? Simply choose your preferred airfares, hotels, experiences and rental cars and you'll have some extra change bouncing around in your pockets!

On top of that, you'll be excited to hear that you can pick from 500 airline partners and more than 500,000 accommodations across the globe.

With unlimited options to pick from, our packages will help you design that vacation you've long dreamed about.

Ready to cross Cayo Largo off your world map?

Car Rentals in Cayo Largo

Hi there, globetrotter. We know you want to get the most out of your getaway, so why not check out car rentals in Cayo Largo? Book with Orbitz and get your adventure on the road today!

Unfortunately, there aren't any car rental outlets next to Vilo Acuna Airport. You'll have to hail a cab or investigate public transport if you want to journey the 5 miles into town.

Nearest Airports to Cayo Largo

Airports. They can be a bit of a hassle, but traveling would definitely be a lot harder without them! The closest to Cayo Largo is Vilo Acuna Airport (CYO). It's located 5 miles from the downtown area.

Popular Places to Visit Near Cayo Largo

If you're keen to venture a little further afield, you could check out Playa Giron, which is 40 miles away. Museum of the Intervention is just one of the interesting things to do here. Los Peces Caves is another place to visit while you are here.

Join Orbitz Rewards

Life isn't much fun without those little perks and extra savings. You'll have instant Orbucks when you start booking with us. This straightforward system lets you gain rewards lightning fast!

Earn gold or platinum status for perks and added extras at all Orbitz Rewards VIP Hotels. How do you do that? Just stay four nights for gold membership and 12 nights for platinum in a year. And how do you redeem Orbucks? It's a piece of cake — just use your Orbitz Rewards points on your next booking.

No Cancellation Fees

Dusted off your passport, booked your big adventure but now you can't go? No need to worry — we make canceling simple and straightforward by not requesting a fee.^ Act promptly and your selected hotel and airline might do the same!