Portland to San Diego Intro 12

Grab great fares on Portland to San Diego flights with Orbitz, your #1 source for discount international and domestic air tickets. Our cutting-edge mobile tools and great online search functionality make booking your next budget trip a breeze.

Mobile Apps for Exclusive Deals on Flights From Portland to San Diego

You don’t have to sit down at a computer to find the latest flight bargains. Orbitz offers a mobile app for Android, iPhone, and tablet devices, which will keep you alert to fantastic fares, hotel discounts, and more great savings. The app gives you real-time low fares for flights from Portland to San Diego and lets you book your hotel room with a few simple clicks.

Find Your Portland to San Diego Flights, Car, and Hotel in One Place

Orbitz gives you the latest deals on air fares, hotels, cruises, and car rentals at up to 50% off. Booking your flights from Portland to San Diego is easy whether you are using a computer, with the Orbitz mobile app, or through m.orbitz.com on your mobile device’s Web browser.

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Earn Miles for Flights From Portland to San Diego

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Save more with San Diego Flight + Hotel packages

Hotels in San Diego

See all 537 Hotels in San Diego
Paradise Point Resort & Spa
Paradise Point Resort & Spa
1404 Vacation Rd, San Diego
4.0 out of 5.0
3.8 out of 5 (345 reviews)

Paradise Point Resort & Spa is on a private tropical island in San Diego’s Mission Bay. SeaWorld® is a 4-minute drive away over Mission Bay’s South Cove, and ...

$150

$150
Days Inn San Diego Hotel Circle Near SeaWorld
Days Inn San Diego Hotel Circle Near SeaWorld
543 Hotel Circle S, San Diego
3.0 out of 5.0
3.6 out of 5 (1,013 reviews)

Located in San Diego's Mission Valley corridor just off I-8, this San Diego hotel is a half-mile from 2 shopping centers, and within 5 miles of SeaWorld, downtown, ...

$76

$76
The Sofia Hotel
The Sofia Hotel
150 W Broadway, San Diego
3.5 out of 5.0
4.1 out of 5 (417 reviews)

In the heart of downtown San Diego, this historic boutique hotel is 2 blocks from Horton Plaza, 4 blocks from the Gaslamp Quarter, and 6 blocks from the San ...

$120

$120
Urban Boutique Hotel
Urban Boutique Hotel
1654 Columbia Street, San Diego
3.0 out of 5.0
3.9 out of 5 (30 reviews)

Located in Downtown San Diego, this hotel is within a 15-minute walk of Firehouse Museum and Maritime Museum of San Diego. USS Midway Museum and San Diego City ...

$85

$85
Best Western Seven Seas
Best Western Seven Seas
411 Hotel Circle South, San Diego
3.0 out of 5.0
3.6 out of 5 (269 reviews)

Adjacent to I-8, this budget-friendly hotel is within 6 miles of 2 sports stadiums, the Gaslamp Quarter, the convention center, the San Diego Zoo, SeaWorld, ...

$85

$85
Sheraton San Diego Hotel and Marina
Sheraton San Diego Hotel and Marina
1380 Harbor Island Dr, San Diego
4.0 out of 5.0
3.9 out of 5 (469 reviews)

Situated on San Diego Bay with its own marina, the Sheraton San Diego Hotel and Marina is 1 mile (1.6 km) away from San Diego International Airport, and just ...

$99

$99
Hilton San Diego Bayfront
Hilton San Diego Bayfront
1 Park Blvd, San Diego
4.0 out of 5.0
4.1 out of 5 (324 reviews)

Rising 30 stories above San Diego Bay, this modern Hilton is adjacent to the San Diego Convention Center, across from Petco Park, and 3 blocks from the Gaslamp ...

$169

$169
The Dana on Mission Bay, BW Premier Collection
The Dana on Mission Bay, BW Premier Collection
1710 W Mission Bay Dr, San Diego
3.5 out of 5.0
3.9 out of 5 (490 reviews)

Adjacent to San Diego's Mission Bay, this 13-acre hotel is within 2 miles of SeaWorld and Mission Beach, and 6 miles of the San Diego Zoo.

$107

$107
Mission Valley Resort
Mission Valley Resort
875 Hotel Cir South, San Diego
3.0 out of 5.0
2.1 out of 5 (18 reviews)

Comprising 8 buildings in a tropical setting near the foothills of Mission Valley, and convenient to I-8, this resort is 2 miles from Old Town and 4 miles from ...

$55

$55
Marriott Vacation Club Pulse, San Diego
Marriott Vacation Club Pulse, San Diego
701 A St, San Diego
3.5 out of 5.0
3.7 out of 5 (83 reviews)

Marriott Vacation Club Pulse, San Diego, built around the historical San Diego Symphony Hall, is centrally located downtown, close to Balboa Park, San Diego ...

$149

$149

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 48 hours. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.