Selected fares from Key West to San Diego

Key West to San Diego Intro 48

Searching for deals for cheap flights from Key West to San Diego? Orbitz has your guaranteed low prices and offers cutting-edge mobile tools to make it easy to find bargain air tickets.

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Smartphone users can download the Orbitz app for Android and iPhone devices to get information on low fare deals for flights from Key West to San Diego anytime. These apps allow users to not only book tickets but check on their flight status and get the details they need to find the right departure gate—right on their mobile device.

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Orbitz makes it simple to earn points for your frequent flyer program when you book certain flights from Key West to San Diego. Just enter the account number associated with your frequent flyer program during the booking process, and your points or miles will be added after you complete your flight.

Orbitz Flight Alerts Keep You Updated

Along with offering bargain prices for Key West to San Diego flights, Orbitz also features free flight alerts that inform you of any abrupt changes to your travel itinerary. You can opt to have your alerts sent by email, voice, or text message. Orbitz will even forward the alerts to your contacts, who may need to adjust their plans for picking you up at the terminal.

Get Bargain Fares for Key West to San Diego Flights

Orbitz makes it quick and easy to find airfare sales and low fare tickets. Decide which airline and flight times you want or, if your schedule is flexible, choose a range of dates to see the best prices.

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Save more with San Diego Flight + Hotel packages

Hotels in San Diego

See all 551 Hotels in San Diego
Best Western Seven Seas
Best Western Seven Seas
411 Hotel Circle South, San Diego
3.0 out of 5.0
3.6 out of 5 (271 reviews)

Adjacent to I-8, this budget-friendly hotel is within 6 miles of 2 sports stadiums, the Gaslamp Quarter, the convention center, the San Diego Zoo, SeaWorld, ...

$75

$75
Days Inn San Diego Hotel Circle Near SeaWorld
Days Inn San Diego Hotel Circle Near SeaWorld
543 Hotel Circle S, San Diego
3.0 out of 5.0
3.6 out of 5 (1,017 reviews)

Located in San Diego's Mission Valley corridor just off I-8, this San Diego hotel is a half-mile from 2 shopping centers, and within 5 miles of SeaWorld, downtown, ...

$69

$69
The Sofia Hotel
The Sofia Hotel
150 W Broadway, San Diego
3.5 out of 5.0
4.1 out of 5 (421 reviews)

In the heart of downtown San Diego, this historic boutique hotel is 2 blocks from Horton Plaza, 4 blocks from the Gaslamp Quarter, and 6 blocks from the San ...

$113

$113
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
1 Market Pl, San Diego
4.0 out of 5.0
4.3 out of 5 (276 reviews)

This expansive highrise hotel towers over San Diego Bay next to the Seaport Village retail complex, 1 block from the convention center, and 2 blocks from the ...

$219

$219
Carlsbad By The Sea Resort
Carlsbad By The Sea Resort
850 Palomar Airport Road, Carlsbad
3.0 out of 5.0
3.8 out of 5 (212 reviews)

Guests at Carlsbad By the Sea Resort can cross the street to shop at Barney’s New York and Calvin Klein, just 2 of the more than 90 stores at Carlsbad Premium ...

$104

$104
The Dana on Mission Bay, BW Premier Collection
The Dana on Mission Bay, BW Premier Collection
1710 W Mission Bay Dr, San Diego
3.5 out of 5.0
3.9 out of 5 (496 reviews)

Adjacent to San Diego's Mission Bay, this 13-acre hotel is within 2 miles of SeaWorld and Mission Beach, and 6 miles of the San Diego Zoo.

$139

$139
Hilton San Diego Bayfront
Hilton San Diego Bayfront
1 Park Blvd, San Diego
4.0 out of 5.0
4.1 out of 5 (324 reviews)

Rising 30 stories above San Diego Bay, this modern Hilton is adjacent to the San Diego Convention Center, across from Petco Park, and 3 blocks from the Gaslamp ...

$173

$173
Mission Valley Resort
Mission Valley Resort
875 Hotel Cir South, San Diego
2.5 out of 5.0
2.3 out of 5 (23 reviews)

Comprising 8 buildings in a tropical setting near the foothills of Mission Valley, and convenient to I-8, this resort is 2 miles from Old Town and 4 miles from ...

$57

$57
Wyndham San Diego Bayside
Wyndham San Diego Bayside
1355 N Harbor Drive, San Diego
3.5 out of 5.0
3.7 out of 5 (308 reviews)

Just west of the downtown core, this San Diego hotel is across the street from the cruise ship terminal, Coronado ferry, and the Maritime Museum. The Gaslamp ...

$135

$135
Sheraton San Diego Hotel and Marina
Sheraton San Diego Hotel and Marina
1380 Harbor Island Dr, San Diego
4.0 out of 5.0
3.9 out of 5 (471 reviews)

Situated on San Diego Bay with its own marina, the Sheraton San Diego Hotel and Marina is 1 mile (1.6 km) away from San Diego International Airport, and just ...

$139

$139

Fare, taxes & fees: Fares include all taxes and fees, except baggage fees. Rates shown reflect fares found by other Orbitz users over the past 48 hours. Due to rapidly changing airline prices & seat availability, these fares may no longer be available.

Refunds/changes/cancellations: Itinerary changes, if permitted for the fare, will have a $30 service fee charged by Orbitz. Additional airline charges may apply.

Other conditions: Schedules, fares and rules are subject to change without notice. Seats are limited and may not be available on all flights/dates or in all markets. Lower fares may be available. Fares will not be honored retroactively or in exchange for any wholly/partially unused ticket. Tickets are non-transferable and non-refundable. Fare rules are provided for the selected itinerary before booking.