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Featured Mississippi River Spa Resorts & Hotels

Estimated price for 1 night/2 adults

Big Cypress Lodge
Big Cypress Lodge
5.0 out of 5.0 1 Bass Pro Drive, Memphis, TN
Free Cancellation
$205
4.7/5 (42 reviews)

I would say the only drawback is no pool, but an in-room jacuzzi/bath tub is excellent and all the other plusses at this hotel such is excellent staff and amenities far make up for that.

Reviewed on Jul 12, 2019
Guests staying at Big Cypress Lodge enjoy access to a full-service spa, a 24-hour fitness center, and free WiFi in public areas. Valet parking is offered for ...
SpaFamily FriendlyRoomservice
Hotel Blackhawk, Autograph Collection
Hotel Blackhawk, Autograph Collection
4.0 out of 5.0 200 E 3rd St, Davenport, IA
Free Cancellation
$169
4.7/5 (18 reviews)

Beautiful hotel Great staff Picture perfect Blah, blah,

Reviewed on Sep 4, 2018
Guests of Hotel Blackhawk, Autograph Collection enjoy a full-service spa, an indoor pool, and a 24-hour fitness center. Free valet and self parking are available—or ...
SpaPet FriendlyWifi
Hotel Julien Dubuque
Hotel Julien Dubuque
3.5 out of 5.0 200 Main Street, Dubuque, IA
Free Cancellation
$109
4.5/5 (102 reviews)

Old school elegance was very pleasant. The spa was luxuriously amazing. This was a very needed vacation

Reviewed on Jul 6, 2019
At Hotel Julien Dubuque, guests enjoy a full-service spa, a nightclub, and an indoor pool. There's free parking, as well as a free airport shuttle (available ...
SpaDiningFree Parking
The Chase Park Plaza Royal Sonesta St. Louis
The Chase Park Plaza Royal Sonesta St. Louis
4.5 out of 5.0 212 N Kingshighway, St. Louis, MO
Free Cancellation
$159
4.4/5 (113 reviews)

We always love staying here. It has an old world charm, is extremely clean, and everyone who represents this hotel is very courteous and helpful.

Reviewed on Jul 15, 2019
Guests of The Chase Park Plaza Royal Sonesta St. Louis have access to an outdoor pool, a health club, and free WiFi in public areas. Parking is available for ...
SpaDiningConcierge
Four Seasons Hotel St Louis
Four Seasons Hotel St Louis
5.0 out of 5.0 999 North Second Street, St. Louis, MO
Free Cancellation
$319
4.4/5 (23 reviews)

Nice environment but room was old and needed an update. Couldn’t get the air comfortable and found old hair in the sheets

Reviewed on Oct 21, 2018
Guests of Four Seasons Hotel St Louis have access to a full-service spa, a casino, and an outdoor pool. If you decide to drive, there's free parking. The 24-hour ...
SpaCasinoLuxury
Rhythm City Casino and Resort
Rhythm City Casino and Resort
3.5 out of 5.0 7077 Elmore Ave., Davenport, IA
Free Cancellation
$110
4.3/5 (6 reviews)

Overall very clean. Staff very courteous. Great food selection and spa 2 thumbs up

Reviewed on Apr 29, 2019
Built in 2016, the brand new Rhythm City Casino and Resort features a casino, an indoor pool, and a 24-hour fitness center. Free valet and self parking are available—or ...
SpaCasinoDining
Ramada by Wyndham Galena Hotel and Day Spa
Ramada by Wyndham Galena Hotel and Day Spa
2.5 out of 5.0 11383 US Highway 20, Galena, IL
Free Cancellation
$78
4.0/5 (82 reviews)

Paperwork was ready for me at registration. Lobby is nice. Pool is huge

Reviewed on Jun 8, 2019
Ramada by Wyndham Galena Hotel and Day Spa features a full-service spa, an indoor pool, and a 24-hour fitness center. You can put free parking to good use if ...
SpaPoolBreakfast
Best Western Plus Minneapolis-Northwest
Best Western Plus Minneapolis-Northwest
2.5 out of 5.0 2050 Freeway Blvd, Brooklyn Center, MN
Free Cancellation
$93
3.2/5 (87 reviews)

Nice. Your typical best western. It is in an older more industrial neighborhood. Its close to Top Golf. Which is why we stayed here.

Reviewed on May 27, 2019
At Best Western Plus Minneapolis-Northwest, guests enjoy features like an indoor pool, a fitness center, and a spa tub. Free parking is available if you drive. ...
SpaAir ConditioningFamily Friendly
Fitz Casino & Hotel Tunica
Fitz Casino & Hotel Tunica
3.5 out of 5.0 711 Lucky Ln, Robinsonville, MS
$30
2.9/5 (100 reviews)

The room rates were very reasonable. I wish the rooms had microwaves.

Reviewed on Feb 22, 2019
At Fitz Casino & Hotel Tunica, guests enjoy a casino, an indoor pool, and a fitness center. If you decide to drive, there's free valet parking. The front desk ...
SpaDiningCasino

Find the Best Mississippi River Spa Hotels

Experience ultimate relaxation at a Mississippi River hotel and spa, and let your worries melt away. If you’re looking for a vacation that’s all about you (and maybe your significant other, too), you’ve found your match. Whether you want an expert massage or fantastic facial, you’re sure to get special treatment at these properties. Add in all the amenities of a hotel or resort, top it off with personalized service, and you’ve got a recipe for the best vacation ever.

Relax at Mississippi River spa resorts
At Mississippi River hotels with spas, everything is taken care of from the moment you arrive. Top-notch service begins at check-in and doesn’t end until you’re on your way home. In your room, you’ll find quality bath products and super-soft sheets that will make you feel like you’re already in the spa. After all, getting a good night’s rest is an important part of having a relaxing getaway. 

Thinking about taking a weekend spa getaway to Mississippi River? We have two words for you: girls’ trip! Grab your crew and start browsing Mississippi River spa hotels. You’ll find options from $30 to $319. If you have romance on the mind, hotel spas are perfect for you, too. From your room to the sauna, these places were practically made for romantic getaways. Go ahead and book that couples’ massage, because you’re about to have your best weekend yet.

Recent Spa Resorts & Hotels Reviews

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.