Beginning of main content

Earn Orbucks instantly: $1 Orbuck = $1 USD, good toward hotels

Save up to 50% on select hotels with Insider Prices

Book on the app to instantly earn 5% on 350,000+ hotels

Tonight
This weekend
Oct 25 - Oct 27
Next weekend
Nov 1 - Nov 3

Featured Mississippi River Romantic Getaways & Hotels

Goldmoor Inn
Goldmoor Inn
4.0 out of 5.0 9001 W.Sand Hill Rd, Galena, IL
$252
5.0/5 (1 reviews)

Stayed in the Mississippi Suite and the views are incredible!

Reviewed on Jun 17, 2019
Goldmoor Inn features free WiFi in public areas, 2 meeting rooms, and a business center. Free parking is included with your stay. Front-desk staff can assist ...
RomanticRiverBreakfast
Lefevre Inn and Resort
Lefevre Inn and Resort
2.5 out of 5.0 9917 West Deininger Lane, Galena, IL
$99
4.8/5 (6 reviews)

Beautiful inside and out. Never heard another person. Staff was lovely and the grounds were gorgeous even had a christmas tree in our room. We absolutely will be back

Reviewed on Dec 4, 2018
Lefevre Inn and Resort features free WiFi in public areas, spa services, and a seasonal outdoor pool. If you plan to drive, free parking is available. Helpful ...
RomanticFireplacePet Friendly
Big Cypress Lodge
Big Cypress Lodge
5.0 out of 5.0 1 Bass Pro Drive, Memphis, TN
$205
4.7/5 (47 reviews)

The rooms are amazing . The front desk professional and exceeded my expectations. The service at the restaurant “lookout” wonderful. The food at the “lookout” spectacular

Reviewed on Sep 11, 2019
Guests staying at Big Cypress Lodge enjoy access to a full-service spa, a 24-hour fitness center, and free WiFi in public areas. Valet parking is offered for ...
RomanticFamily FriendlyRoomservice
Hotel Julien Dubuque
Hotel Julien Dubuque
3.5 out of 5.0 200 Main Street, Dubuque, IA
$99
4.5/5 (106 reviews)

I liked everything about our stay. The only thing I didn’t like was that no breakfast was included. Also there was a wedding and parking was no good had to drive around for a good 20 minutes til we could find a parking stop in their lot.

Reviewed on Oct 4, 2019
At Hotel Julien Dubuque, guests enjoy a full-service spa, a nightclub, and an indoor pool. There's free parking, as well as a free airport shuttle (available ...
RomanticDiningFree Parking
The Westin St. Louis
The Westin St. Louis
4.5 out of 5.0 811 Spruce St, St. Louis, MO
Free Cancellation
$139
4.5/5 (86 reviews)

Everything was great from the Parking attendant to the check in!

Reviewed on Jan 28, 2019
At The Westin St. Louis, guests have access to a 24-hour fitness center, free WiFi in public areas, and conference space. Parking is available for USD 30 per ...
RomanticSportsDining
The Chase Park Plaza Royal Sonesta St. Louis
The Chase Park Plaza Royal Sonesta St. Louis
4.5 out of 5.0 212 N Kingshighway, St. Louis, MO
$179
4.4/5 (115 reviews)

We always love staying here. It has an old world charm, is extremely clean, and everyone who represents this hotel is very courteous and helpful.

Reviewed on Jul 15, 2019
Guests of The Chase Park Plaza Royal Sonesta St. Louis have access to an outdoor pool, a health club, and free WiFi in public areas. Parking is available for ...
RomanticDiningConcierge
Hollywood Casino Tunica
Hollywood Casino Tunica
3.0 out of 5.0 1150 Casino Strip Resort Blvd, Robinsonville, MS
Free Cancellation
$39
3.9/5 (114 reviews)

I liked the atmosphere. Didn’t like the fact that while waiting to check in cigarette smoke was in the air😒

Reviewed on Oct 11, 2019
Hollywood Casino Tunica features a casino, an indoor pool, and a fitness center. A stay here includes free valet parking. The 24-hour front desk has staff standing ...
RomanticDiningParking
Lodge at Grant's Trail
Lodge at Grant's Trail
3.5 out of 5.0 4398 Hoffmeister Avenue, St. Louis, MO
$120
3.2/5 (4 reviews)

We loved the unique room design. The room was clean, no funky hotel smell. We will come back here for sure on our next visit in the city.

Reviewed on Jul 15, 2019
Lodge at Grant's Trail features free WiFi in public areas, a meeting room, and coffee in a common area. You can take advantage of free parking if you drive. ...
RomanticBreakfastHiking
Historical 'kage House' Short Term Rental Located in "old Town Cape"
Historical 'kage House' Short Term Rental Located in "old Town Cape"
Cape Girardeau, MO
This apartment is a smoke-free apartment building.
RomanticHistoricalKitchen

Mississippi River Romantic Getaways

Maybe you want to make this year’s anniversary truly special, or you need a couple’s getaway to reconnect. Whatever your reason, Orbitz has romantic hotels in Mississippi River that can add a spark to any vacation. 

Love and low rates are in the air
We know love is priceless, but great hotels aren’t. No worries; Orbitz has hotels perfect for a weekend couple’s getaway that won’t break the bank. When you book through Orbitz you can:

  • Choose from over 1886 hotels. We have everything from cozy and quaint to luxury suites that pull out all the stops for honeymoons and special occasions.
  • Pick the price that fits your budget. Rates range from $39 to $252Looking for something extra special? 
  • Read through 479 reviews to see which hotels do all the little things that add some “wow” to your experience.

A romantic hotel by any other name
These hotels do everything they can to create the right ambiance. Your rooms will have thoughtful touches like premium bedding, designer toiletries and whirlpool bath tubs. There is some great stuff outside your room, too. Think full-service spas, hot tubs, infinity pools and secluded gardens. Many also have gourmet restaurants on-site, which means you won’t have to go far to have a romantic dinner. A stay at one of these places will give you all the ingredients for a romantic Mississippi River weekend getaway.

Recent Romantic Getaways & Hotels Reviews

*Price based on the lowest price found within past 24 hours and based upon one night stay for two adults over the next thirty days. Prices and availability subject to change. Additional terms may apply.