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South Carolina Vacations

Your trip

Hotel options

Hotel stay must be within date range of Leave and Return.

Room 1
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Your South Carolina vacation

Forget cookie-cutter, pre-packaged vacations. When it comes to South Carolina vacations, Orbitz lets you choose the flight and hotel that fits your calendar and price point. Mix and match your South Carolina travel plans, and enjoy discounts you won't find when you book separately.

Get expert advice on South Carolina travel
Narrow down the best hotels, attractions and activities for your lifestyle and budget. Orbitz offers free 24/7 support so you can plan your South Carolina vacations with ease. Call a specialist anytime at 1-800-504-3248.

Sales and exclusive offers on South Carolina travel
If you’re on the lookout for South Carolina travel deals, sign up to receive deals by e-mail. You'll find the latest scoop on discounts, resort credits and more. You can also follow us on Facebook  and Twitter for special promotions and savings.

View South Carolina vacation savings at a glance
See your vacation savings on the Orbitz Matrix Display. View all your flight and hotel options, and see what you can save on South Carolina vacations when you book together. It's all you need to know in just one click.

Add activities to South Carolina vacations
Skip those long lines, and bundle your flight and hotel vacation packages with activities ahead of time. Book tickets to sightseeing tours, sporting events and more.

Receive free South Carolina travel alerts
Be the first to know about flight delays, weather and other events. Receive free Orbitz Care Alerts by phone, e-mail or text. Plus, you can have free alerts sent to up to six other people.

More on South Carolina from the Orbitz Blog

South Carolina Vacation Packages

Hotel only $127

1 Hyatt Regency Greenville

4 stars
3.8 / 5 48 reviews

220 North Main St Map

Free High-Speed Internet, Free Parking

Urban retreat located in downtown GreenvilleThe Hyatt Regency Greenville is a stylish urban retreat in the heart of downtown Greenville. With an eight-story atrium lobby, complete with a waterfall, the sense of retreat and relaxation starts as soon as guests walk through... More

Hotel only $59

2 Dunes Village Resort

4 stars
4.3 / 5 234 reviews

5300 North Ocean Boulevard Map

35% OFF, LIMITED TIME OFFER

Spacious condos with ocean views and full kitchens in Myrtle BeachA sprawling indoor water park -- the largest of its kind in Myrtle Beach at 30,000 square feet -- fuels endless hours in the lazy river, Silly Submarine and waterslides at the Dunes Village Resort. Visitors... More

Hotel only $99

3 Embassy Suites North Charleston - Airport/Hotel & Convention Center

3 stars
4.3 / 5 35 reviews

5055 International Boulevard Map

Free cooked-to-order breakfast, Evening Reception

Enjoy a convenient location at Embassy Suites North Charleston – Airport/Hotel & Convention. Take the complimentary shuttle to Charleston International Airport just two miles away and walk to over 30 restaurants in the local neighborhood. Our Charleston, SC hotel is... More

Hotel only $69

4 Sheraton Columbia Downtown Hotel

3 stars
3.8 / 5 37 reviews

1400 Main Street Map

Save 25% on your stay

Historic Columbia downtown hotel near shopping, attractionsThe Sheraton Columbia Downtown Hotel is located on Main Street in the heart of Columbia, South Carolina. The hotel is within walking distance to shops, restaurants and museums, and a short drive from Columbia ... More

Hotel only $134

5 Francis Marion Hotel

4 stars
4.0 / 5 223 reviews

387 King Street Map

Winter Sale - Save 20% on Deluxe Accommodations

Historic charm, modern conveniences in downtown CharlestonThe Francis Marion Hotel was built in 1924, completely renovated in 1996 with a $12 million grant from the National Trust for Historic Preservation, but there's still plenty of old-fashioned charm. The rooms... More

Hotel only $98

6 Holiday Inn Express & Suites GREENVILLE-DOWNTOWN

3 stars
4.0 / 5 32 reviews

407 North Main Street Map

Greenville Hotel's Keeping Southern Charm In Business Greenville is home to some of the Upstate's largest and most exciting industries, including Fluor, Windstream, GE, Michelin and BMW. This Greenville, SC hotel's location is close to the hustle and bustle of Main Street... More

Hotel only $111

7 Marina Inn at Grande Dunes

5 stars
4.5 / 5 208 reviews

8121 Amalfi Place Map

Save 25% Off

Luxury amenities and multiple recreational activities in Myrtle BeachWaterfront views and 2,200 acres of lush landscape elevate the luxury at the Marina Inn at Grande Dunes resort between the Atlantic Ocean and the Intracoastal Waterway. The master-planned community... More

Hotel only $69

8 SpringHill Suites by Marriott Charleston North

3 stars
4.1 / 5 150 reviews

7535 North Forest Drive Map

Charleston airport hotel with free Internet and continental breakfastCompleted in June 2009, the SpringHill Suites by Marriott Charleston North hotel offers 115 spacious suites and a free continental breakfast buffet. Free wired and wireless high-speed Internet service... More

Hotel only $70

9 Wingate by Wyndham Columbia / Ft. Jackson

3 stars
3.8 / 5 83 reviews

8300 Two Notch Road Map

Stay 3, Save 20%

Budget-friendly Fort Jackson, Columbia hotel with free Wi-Fi, breakfastWingate by Wyndham Columbia/Ft. Jackson is located near the intersection of I-77 and I-20 in Columbia, South Carolina. Guests in town visiting the University of South Carolina and Fort Jackson -- the... More

Hotel only $379

10 The Vendue

4 stars
4.3 / 5 117 reviews

19 & 26 Vendue Range Map

Fall Sale, Save 10%

Downtown Charleston boutique hotel with great dedication to the arts The Vendue Inn offers a prime location in historic French Quarter and upscale services and amenities. This hotel is a combination of two boutique hotels ? 19 Vendue and 26 Vendue. Located just a block... More