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South Carolina Vacations

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Hotel stay must be within date range of Leave and Return.

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Your South Carolina vacation

Forget cookie-cutter, pre-packaged vacations. When it comes to South Carolina vacations, Orbitz lets you choose the flight and hotel that fits your calendar and price point. Mix and match your South Carolina travel plans, and enjoy discounts you won't find when you book separately.

Get expert advice on South Carolina travel
Narrow down the best hotels, attractions and activities for your lifestyle and budget. Orbitz offers free 24/7 support so you can plan your South Carolina vacations with ease. Call a specialist anytime at 1-800-504-3248.

Sales and exclusive offers on South Carolina travel
If you’re on the lookout for South Carolina travel deals, sign up to receive deals by e-mail. You'll find the latest scoop on discounts, resort credits and more. You can also follow us on Facebook  and Twitter for special promotions and savings.

View South Carolina vacation savings at a glance
See your vacation savings on the Orbitz Matrix Display. View all your flight and hotel options, and see what you can save on South Carolina vacations when you book together. It's all you need to know in just one click.

Add activities to South Carolina vacations
Skip those long lines, and bundle your flight and hotel vacation packages with activities ahead of time. Book tickets to sightseeing tours, sporting events and more.

Receive free South Carolina travel alerts
Be the first to know about flight delays, weather and other events. Receive free Orbitz Care Alerts by phone, e-mail or text. Plus, you can have free alerts sent to up to six other people.

More on South Carolina from the Orbitz Blog

South Carolina Vacation Packages

Hotel only $120

1 Holiday Inn Express & Suites GREENVILLE-DOWNTOWN

3 stars
4.0 / 5 40 reviews

407 NORTH MAIN STREET Map

Greenville Hotel's Keeping Southern Charm In Business Greenville is home to some of the Upstate's largest and most exciting industries, including Fluor, Windstream, GE, Michelin and BMW. This Greenville, SC hotel's location is close to the hustle and bustle of Main Street... More

Hotel only $99

2 The Breakers Resort

3 stars
3.9 / 5 154 reviews

2008 North Ocean Blvd. Map

Save 25%

The Breakers Resort Hotel has been serving and pleasing guests that continue to return year after year- a true Myrtle Beach tradition. Centrally located oceanfront at 21st Avenue North, and now anchoring the planned unit redevelopment for the city, guests will have easy... More

Hotel only $79

3 SpringHill Suites by Marriott Charleston North

3 stars
4.2 / 5 188 reviews

7535 North Forest Drive Map

Charleston airport hotel with free Internet and continental breakfastCompleted in June 2009, the SpringHill Suites by Marriott Charleston North hotel offers 115 spacious suites and a free continental breakfast buffet. Free wired and wireless high-speed Internet service... More

Hotel only $66

4 Wingate by Wyndham Columbia / Ft. Jackson

3 stars
3.7 / 5 111 reviews

8300 Two Notch Road Map

Stay 3, Save 20%

Budget-friendly Fort Jackson, Columbia hotel with free Wi-Fi, breakfastWingate by Wyndham Columbia/Ft. Jackson is located near the intersection of I-77 and I-20 in Columbia, South Carolina. Guests in town visiting the University of South Carolina and Fort Jackson -- the... More

Hotel only $150

5 Francis Marion Hotel

4 stars
3.9 / 5 283 reviews

387 King Street Map

Historic charm, modern conveniences in downtown CharlestonThe Francis Marion Hotel was built in 1924, completely renovated in 1996 with a $12 million grant from the National Trust for Historic Preservation, but there's still plenty of old-fashioned charm. The rooms... More

Hotel only $135

6 Hyatt Regency Greenville

4 stars
3.8 / 5 77 reviews

220 North Main St Map

Rate includes Breakfast for 2

Urban retreat located in downtown GreenvilleThe Hyatt Regency Greenville is a stylish urban retreat in the heart of downtown Greenville. With an eight-story atrium lobby, complete with a waterfall, the sense of retreat and relaxation starts as soon as guests walk through... More

Hotel only $279

7 Marina Inn at Grande Dunes

5 stars
4.5 / 5 268 reviews

8121 Amalfi Place Map

Stay 7+ Nights – Get 2 Nights Free

Luxury amenities and multiple recreational activities in Myrtle BeachWaterfront views and 2,200 acres of lush landscape elevate the luxury at the Marina Inn at Grande Dunes resort between the Atlantic Ocean and the Intracoastal Waterway. The master-planned community... More

Hotel only $87

8 BEST WESTERN PLUS Airport Inn & Suites

3 stars
3.6 / 5 243 reviews

2470 Prospect Drive Map

Save 15% on your stay

Airport hotel with free amenities close to Charleston attractionsThe Charleston Best Western Airport Inn & Suites offers convenient access to the Charleston Coliseum, convention center, historic downtown Charleston and the airport. The rooms and suites are spacious,... More

Hotel only $68

9 BEST WESTERN Executive Inn & Suites

3 stars
3.7 / 5 58 reviews

1720 Bush River Road Map

Save 10% on your stay

Welcome to BEST WESTERN Executive Inn & Suites! Hotels near USC cater to guests who are in town for campus events from graduation to a semester of teaching, and this property provides comfortable accommodations ideal for extended stays. Looking for properties that have... More

Hotel only $241

10 Belmond Charleston Place

5 stars
4.5 / 5 189 reviews

205 Meeting Street Map

Save 15%

Luxurious Charleston hotel with two top-rated restaurants on-siteThe luxurious Belmond Charleston Place features two of the city's finest restaurants on the premises. Many of downtown's historic sites and museums are within walking distance. The hotel boasts a... More