By clicking, I agree to the terms

Greenville Vacations

Your trip

Hotel options

Hotel stay must be within date range of Leave and Return.

Room 1
Age categories
Ages of children at time of trip (for pricing, discounts)

Your Greenville vacation

From family vacations to last-minute romantic getaways, make Orbitz your first and only stop for Greenville vacations. You can customize your trip with flights, hotels and activities to match your travel plans and tastes. Sweeten the pot with extra savings when you book your flight and hotel together.

Create your own Greenville travel plans
Build your own Greenville vacation itinerary. Choose a flight that matches your schedule and a hotel with the amenities you need. Book them together for extra discounts you won't find when booking separately.

Find Greenville travel discounts
Be the first to know about exclusive offers and last-minute deals on Greenville travel. Sign for our deals e-mail , or follow us on Twitter and Facebook for promo codes, discounts and more. Our global network of travel experts find big-time savings and travel deals just for you.

Get Greenville travel support 24/7
Reach out to an Orbitz travel specialist for Greenville vacation assistance. Our specialists are available around the clock at 1-800-504-3248. We can even help with last-minute Greenville vacations.

Sign up for free Greenville travel alerts
Make travel plans smoother with Orbitz Care Alerts. Receive real-time info about flight delays, weather and other events via phone, e-mail or text. Keep up to six other people in the loop with travel alerts, too.

Scope out your Greenville vacation options and savings
With the Orbitz Matrix Display, you can view all your flight and hotel options quickly. Plus, you'll see what you can save on your travel packages when you book them together.
 

Sign up to receive our best deals

Get insider access to our best hotel deals, coupons and more!

Greenville Vacation Packages

Hotel only $163

1 Hyatt Regency Greenville

4 stars
3.8 / 5 47 reviews

220 North Main St Map

Rate includes Breakfast for 2

Urban retreat located in downtown GreenvilleThe Hyatt Regency Greenville is a stylish urban retreat in the heart of downtown Greenville. With an eight-story atrium lobby, complete with a waterfall, the sense of retreat and relaxation starts as soon as guests walk through... More

Hotel only $169

2 The Westin Poinsett, Greenville

4 stars
4.1 / 5 36 reviews

120 South Main Street Map

Save 30% on your stay

Four-Diamond hotel in downtown GreenvilleThe elegant art deco-style Westin Poinsett Greenville is an oasis in the heart of downtown Greenville, providing amenities and services for those travelling for both business and pleasure. Charming Main Street shops and a vibrant... More

Hotel only $58

3 Sleep Inn at TD Convention Center

2 stars
3.6 / 5 20 reviews

231 N Pleasantburg Drive Map

The Sleep Inn at TD Convention Center is within walking distance to the TD Convention Center and just two miles from Bon Secours Wellness Arena, Bob Jones University, Peace Center and Greenville Technical College. Paris Mountain State Park, Falls Park on the Reedy, Fluor... More

Hotel only $134

4 Holiday Inn Express & Suites GREENVILLE-DOWNTOWN

3 stars
4.0 / 5 32 reviews

407 North Main Street Map

Greenville Hotel's Keeping Southern Charm In Business Greenville is home to some of the Upstate's largest and most exciting industries, including Fluor, Windstream, GE, Michelin and BMW. This Greenville, SC hotel's location is close to the hustle and bustle of Main Street... More

Hotel only $69

5 Quality Inn & Suites Greenville

2 stars
Not yet reviewed

10 Mills Ave. Map

Downtown location, Just minutes away from the Historic Downtown of Greenville, SC. Greenville Memorial Hospital is only mile away. Walking distance to shops and uptown. Free Wi-Fi and Wired internet in all rooms. All of our guest rooms are smoke-free and offer... More

Hotel only $69

6 Comfort Inn & Suites

2 stars
3.8 / 5 46 reviews

831 Congaree Road Map

The Comfort Inn & Suites hotel is located in a prime area of Greenville, minutes from Bob Jones University, Furman University, Palmetto Expo Center. We offer many amenities and features, including a free deluxe continental breakfast with hot and cold items as well as a... More

Hotel only $104

7 Drury Inn & Suites Greenville

3 stars
4.5 / 5 21 reviews

10 Carolina Point Parkway Map

The Extras Aren't Extra at Drury Hotels. Your great rate includes FREE hot food and cold beverages at our 5:30 Kickback. FREE hot breakfast, FREE wireless Internet access and FREE long distance. Our 5:30 Kickback includes a rotating menu of hot and cold items, beer, wine,... More

Hotel only $182

8 Courtyard Greenville Downtown

3 stars
4.4 / 5 5 reviews

50 West Broad St Map

Rate includes breakfast

Whether traveling for business or fun,Courtyard by Marriott® Greenville Downtown makes all of your travels successful by providing exactly what you need: spacious,thoughtful guest rooms;the new Courtyard Bistro and services that help you be more productive and... More

Hotel only $82

9 La Quinta Inn & Suites Greenville Haywood

3 stars
4.0 / 5 65 reviews

65 West Orchard Park Dr Map

Value lodging offers proximity to business and recreationLa Quinta Inn and Suites Greenville Haywood offers travelers an affordable, comfortable room and a lot of added value in a location convenient to Greenville businesses and shopping. Located off Interstate 385, La... More

Hotel only $63

10 Baymont Inn & Suites Greenville

2 stars
3.8 / 5 19 reviews

246 Congaree Rd Map

Stay 3, Save 20%

Enjoy sunny southern hospitality at this Baymont Inn and Suites Greenville hotel, close to Interstates 85 and 385 and convenient to Furman University and Bob Jones University. This hotel is also convenient to downtown, the ICAR corporate business park, Greenville... More