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Cherokee Vacations

Your trip

Hotel options

Hotel stay must be within date range of Leave and Return.

Room 1
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Ages of children at time of trip (for pricing, discounts)

Your Cherokee vacation

From family vacations to last-minute romantic getaways, make Orbitz your first and only stop for Cherokee vacations. You can customize your trip with flights, hotels and activities to match your travel plans and tastes. Sweeten the pot with extra savings when you book your flight and hotel together.

Create your own Cherokee travel plans
Build your own Cherokee vacation itinerary. Choose a flight that matches your schedule and a hotel with the amenities you need. Book them together for extra discounts you won't find when booking separately.

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Reach out to an Orbitz travel specialist for Cherokee vacation assistance. Our specialists are available around the clock at 1-800-504-3248. We can even help with last-minute Cherokee vacations.

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Scope out your Cherokee vacation options and savings
With the Orbitz Matrix Display, you can view all your flight and hotel options quickly. Plus, you'll see what you can save on your travel packages when you book them together.

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Cherokee Vacation Packages

Hotel only $89

1 Hampton Inn Cherokee

3 stars
4.2 / 5 34 reviews

185 Tsalagi Road PO Box 1926 Map

Free On The House hot breakfast, Wi-Fi

where native culture still thrives ...welcome to the Hampton Inn Cherokee.The hills of North Carolina call to visitors from around the world. The Hampton Inn® hotel in Cherokee beckons with its premium location in the Blue Ridge Mountains on the Cherokee Indian... More

Hotel only $92

2 Baymont Inn & Suites Cherokee Smoky Mountains

3 stars
4.1 / 5 74 reviews

1455 Acquoni Road Map

Stay 3, Save 20%

Enjoy a taste of hometown hospitality at this completely smoke-free Baymont Inn and Suites Cherokee Smoky Mountains, just off Highways 19 and 441 in beautiful western North Carolina. Convenient to Harrah's Cherokee Casino, Western Carolina University, the Great Smoky... More

Hotel only $124

3 Magnuson Hotel Great Smokies Inn

2 stars
3.4 / 5 12 reviews

1636 Acquoni Road Map

Providing the best location in Cherokee, Magnuson Hotels Great Smokies Inn is the closest hotel to the entrance of the Blue Ridge Parkway and the Great Smoky Mountains National Park. The hotel is within a short drive to Harrahs Casino, Museum of the Cherokee Indians,... More

Hotel only $76

4 Comfort Suites Cherokee

2 stars
3.4 / 5 23 reviews

1223 Tsali Boulevard Map

Comfort Suites is nestled in the heart of Cherokee less than one mile from the entrance to Great Smoky Mountains National Park and the Blue Ridge Parkway. Conveniently located close to many attractions, including Harrah's Cherokee Casino, Museum of the Cherokee Indian,... More

Hotel only $99

5 Days Inn Cherokee/Smokey Mountains

2 stars
3.3 / 5 62 reviews

660 Painttown Road Map

Stay 2, Save 15%

Walk to Harrahs Cherokee Casino directly across the Street. Conveniently located in the heart of the Smokey Mountains. Free Daybreak Lite Continental Breakfast. Close to white Water Rafting, Mountain Biking, Trout Fishing, Hiking, Horseback Riding, Canoeing,... More

Hotel only $58

6 Microtel Inn & Suites by Wyndham Cherokee

2 stars
3.7 / 5 44 reviews

674 Casino Trail Map

Stay 3, Save 20%

A Microtel 2010 -Top 20- Award Winning Hotel This Microtel Inn And Suites by Wyndham Cherokee hotel is close to downtown Cherokee, 0.5 mile to Harrahs Cherokee Casino and less than 2 miles to the Blue Ridge Parkway and the Great Smoky Mountain National Park. Microtel Inn... More

Hotel only $77

7 Holiday Inn Express & Suites CHEROKEE/CASINO

3 stars
3.9 / 5 51 reviews

376 Painttown Road Map

Enjoy Our Cherokee, NC Hotel's Mountain Location Savor the crisp mountain air and beautiful, scenic views while staying at the Holiday Inn Express® Cherokee Casino Hotel. Situated in the heart of the Great Smoky Mountains in picturesque Cherokee, NC, our lodging provides... More

Hotel only $67

8 Comfort Inn On the River

2 stars
3.8 / 5 31 reviews

44 Tsalagi Road Map

Nestled in the heart of the Great Smoky Mountains, we offer a quiet and peaceful getaway for our guests. Our spacious and comfortable rooms offer in room coffee, iron and board, hair dryers, and high speed Internet. Guests can enjoy rooms with a spacious river view... More

9 Smoky Mountain Inn and Suites

2 stars
3.0 / 5 10 reviews


Welcome to the Smoky Mountain Inn & Suites! The hotel is nestled into the relaxing mountains of the Cherokee Indian Reservation located in the most beautiful part of Western North Carolina. The Smoky Mountain Inn & Suites is conveniently located just minutes from... More

Hotel only $64

10 Econo Lodge Cherokee

2 stars
3.7 / 5 23 reviews

20 River Road Highway US 19 Map

Located in the heart of Cherokee offering free shuttle service to Harrahs Casino. Within walking distance to downtown, Cherokee Phoenix Movie Theater, shopping and restaurants. One mile to the Great Smoky Mountain National Park and Harrahs Cherokee Casino. Two miles from... More