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Picayune Vacations

Your trip

Hotel options

Hotel stay must be within date range of Leave and Return.

Room 1
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Your Picayune vacation

From family vacations to last-minute romantic getaways, make Orbitz your first and only stop for Picayune vacations. You can customize your trip with flights, hotels and activities to match your travel plans and tastes. Sweeten the pot with extra savings when you book your flight and hotel together.

Create your own Picayune travel plans
Build your own Picayune vacation itinerary. Choose a flight that matches your schedule and a hotel with the amenities you need. Book them together for extra discounts you won't find when booking separately.

Find Picayune travel discounts
Be the first to know about exclusive offers and last-minute deals on Picayune travel. Sign for our deals e-mail , or follow us on Twitter and Facebook for promo codes, discounts and more. Our global network of travel experts find big-time savings and travel deals just for you.

Get Picayune travel support 24/7
Reach out to an Orbitz travel specialist for Picayune vacation assistance. Our specialists are available around the clock at 1-800-504-3248. We can even help with last-minute Picayune vacations.

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Make travel plans smoother with Orbitz Care Alerts. Receive real-time info about flight delays, weather and other events via phone, e-mail or text. Keep up to six other people in the loop with travel alerts, too.

Scope out your Picayune vacation options and savings
With the Orbitz Matrix Display, you can view all your flight and hotel options quickly. Plus, you'll see what you can save on your travel packages when you book them together.

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Picayune Vacation Packages

Hotel only $59

1 Econo Lodge Picayune

2 stars
2.7 / 5 3 reviews

550 South Lofton Dr. Map

Our hotel offers a complimentary breakfast along with free high speed internet access. All guest rooms include a microwave and a refrigerator, and we also offer an outdoor pool. Enjoy our managers reception every Wednesday with complimentary food and drinks. We are... More

Hotel only $55

2 Days Inn - Picayune

2 stars
1.0 / 5 4 reviews

450 S Lofton Ave Map

Stay 3, Save 20%

Beautifully appointed hotel within one hour of Biloxi casinos and New Orleans. All rooms have microwaves and refrigerators, iron, iron board, coffee maker, hair dryer, clock, free high speed internet, 32 inch flat screen LED color TV. Complimentary Hot Breakfast with hot... More

Hotel only $85

3 Holiday Inn Express & Suites PICAYUNE-STENNIS SPACE CNTR.

3 stars
4.6 / 5 9 reviews


We're the Best Among Picayune, Mississippi Hotels Ideally located along I-59 at exit 4, the Holiday Inn Express Hotel & Suites Picayune is a great home base for area travelers since it's close to Slidell and a short drive from New Orleans. Picayune, Mississippi offers our... More

Hotel only $87

4 Heritage Inn Picayune

1 star
2.3 / 5 3 reviews

1122 Memorial Blvd Map

Welcome to Heritage Inn of Picayune. We offer a convenient location for your lodging needs when visiting New Orleans and surrounding areas. We've recently added a brand new wing to our hotel offering our guests both indoor accessible rooms and outside accessible rooms. ... More

Hotel only $39

5 Super 8 Picayune

2 stars
2.3 / 5 3 reviews

999 Cooper Rd Map

Stay 2, Save 15%

Welcome to the Super 8 Picayune, located near Crosby Arboretum, Picayune Street Fair and NASAs John C. Stennis Space Center. Guest will enjoy amenities like a Free Continental breakfast every morning throughout the stay, guest laundromat and complimentary outdoor parking.... More