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Cape Girardeau Vacations

Your trip

Hotel options

Hotel stay must be within date range of Leave and Return.

Room 1
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Your Cape Girardeau vacation

From family vacations to last-minute romantic getaways, make Orbitz your first and only stop for Cape Girardeau vacations. You can customize your trip with flights, hotels and activities to match your travel plans and tastes. Sweeten the pot with extra savings when you book your flight and hotel together.

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Build your own Cape Girardeau vacation itinerary. Choose a flight that matches your schedule and a hotel with the amenities you need. Book them together for extra discounts you won't find when booking separately.

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Cape Girardeau Vacation Packages

Hotel only $112

1 Holiday Inn Express & Suites CAPE GIRARDEAU I-55

3 stars
4.5 / 5 19 reviews

3253 William Street Map

Welcome to Our Cape Girardeau Hotel. Just off I- 55 at exit 96, the Holiday Inn Express Hotel & Suites Cape Girardeau I-55 offers hotel guests 102 spacious, contemporary suites. Vacation and business guests alike choose these accommodations for a comfortable and... More

Hotel only $69

2 Pear Tree Inn Cape Girardeau

2 stars
3.7 / 5 38 reviews

3248 William Street Map

The Extras Aren't Extra! Your great rate includes FREE evening snacks and beverages. FREE breakfast, FREE wireless Internet access and FREE long distance. Don't miss our great breakfast buffet. Take advantage of FREE popcorn and soda every evening from 3-10 p.m. Rooms... More

Hotel only $89

3 Drury Lodge Cape Girardeau

3 stars
3.9 / 5 31 reviews

104 South Vantage Drive Map

The Extras Aren't Extra at Drury Hotels. Your great rate includes FREE hot food and cold beverages at our 5:30 Kickback. FREE hot breakfast, FREE wireless Internet access and FREE long distance. Our 5:30 Kickback includes a rotating menu of hot and cold items, beer, wine,... More

Hotel only $109

4 Drury Suites Cape Girardeau

3 stars
4.5 / 5 6 reviews

3303 Campster Drive Map

The Extras Aren't Extra at Drury Hotels. Your great rate includes FREE hot food and cold beverages at our 5:30 Kickback. FREE hot breakfast, FREE wireless Internet access and FREE long distance. Our 5:30 Kickback includes a rotating menu of hot and cold items, beer, wine,... More

Hotel only $55

5 Super 8 Cape Girardeau

2 stars
3.1 / 5 17 reviews

2011 North Kingshighway Map

Stay 2, Save 15%

Welcome to the Super 8 in Cape Girardeau, home of the Southeast Missouri State Red Hawks and the St. Francis and Southeast Missouri Hospitals. During your stay with us you can visit the Historic Downtown Area and the several nearby wineries. We offer many amenities... More

Hotel only $119

6 Hampton Inn Cape Girardeau

3 stars
3.0 / 5 1 reviews

103 Cape West Parkway Map

Free On The HouseT hot breakfast, Wi-Fi

escape to the cape...welcome to the Hampton Inn Cape Girardeau. "Cape Girardeau is situated on a hillside, and makes a handsome appearance," the great humorist and novelist Mark Twain said of our Missouri town. From the grand sweep of the Mississippi River to our... More

Hotel only $93

7 Candlewood Suites CAPE GIRARDEAU

2 stars
4.3 / 5 7 reviews

485 South Mt. Auburn Road Map

Experience Historic Cape Girardeau from Hotel's Suites A historic college town in southeastern Missouri, Cape Girardeau is bordered on the east by the mighty Mississippi River. The only all-suite hotel in the area, the Candlewood Suites® Cape Girardeau hotel's spacious... More

Hotel only $81

8 Auburn Place Hotel and Suites

2 stars
4.4 / 5 11 reviews

3265 William St. Map

Free breakfast with over 25 items, indoor heated pool, large whirlpool, free high speed wireless internet in every room, located right off of I-55, microwaves and refrigerators in every room, and much, much more... More