Des Moines Vacations

Hotel options

Hotel stay must be within date range of Leave and Return.

Room 1
*Ages of children at time of trip (for pricing, discounts)


Earn up to 5% on hotels and 1% on flights - It's free!

By clicking, I agree to the terms and conditions.

Your Des Moines vacation

From family vacations to last-minute romantic getaways, make Orbitz your first and only stop for Des Moines vacations. You can customize your trip with flights, hotels and activities to match your travel plans and tastes. Sweeten the pot with extra savings when you book your flight and hotel together.

Create your own Des Moines travel plans
Build your own Des Moines vacation itinerary. Choose a flight that matches your schedule and a hotel with the amenities you need. Book them together for extra discounts you won't find when booking separately.

Find Des Moines travel discounts
Be the first to know about exclusive offers and last-minute deals on Des Moines travel. Sign for our deals e-mail , or follow us on Twitter and Facebook for promo codes, discounts and more. Our global network of travel experts find big-time savings and travel deals just for you.

Get Des Moines travel support 24/7
Reach out to an Orbitz travel specialist for Des Moines vacation assistance. Our specialists are available around the clock at 1-800-504-3248. We can even help with last-minute Des Moines vacations.

Sign up for free Des Moines travel alerts
Make travel plans smoother with Orbitz Care Alerts. Receive real-time info about flight delays, weather and other events via phone, e-mail or text. Keep up to six other people in the loop with travel alerts, too.

Scope out your Des Moines vacation options and savings
With the Orbitz Matrix Display, you can view all your flight and hotel options quickly. Plus, you'll see what you can save on your travel packages when you book them together.

Des Moines Vacation Packages

Hotel only $63

1 Sterling Hotel and Suites

3 stars
4.0 / 5 7 reviews

11428 Forest Ave Map

20% Off

All-Suite Hotel. Every Room is a Suite with a Full-Kitchen and Sofa Sleeper. Many Suites Have Fireplace. Free Wi-Fi. Free Breakfast Served Daily in Clubhouse/Lobby. Four different Suite Types all with King and Queen Size Beds. Outdoor Pool and Spa (Open late May -... More

Hotel only $99

2 Hotel Fort Des Moines

3 stars
3.2 / 5 121 reviews

1000 Walnut St Map

Historic downtown Des Moines hotel with modern amenities, InternetThe historic Hotel Fort Des Moines was built in 1919, and after an extensive renovation was listed on the National Register of Historic Places in 1982. Over the years, the hotel has hosted celebrities such... More

Hotel only $99

3 Des Moines Marriott Downtown

3 stars
4.0 / 5 31 reviews

700 Grand Avenue Map

Rate includes breakfast

Large downtown Des Moines hotel with business and leisure amenitiesThe 33-floor Des Moines Marriott Downtown offers 411 guest rooms, six luxury suites and 15 meeting rooms. The skywalk system connects the hotel with other downtown businesses. High-end amenities include an... More

Hotel only $109

4 Hampton Inn & Suites Des Moines Downtown

3 stars
4.0 / 5 1 reviews

120 SW Water Street Map

Boasting a central location off I-235, in the center of downtown Des Moines, the welcoming Hampton Inn and Suites Des Moines Downtown, IA offers wonderful views over the Des Moines River and easy access to shops, restaurants, businesses and popular attractions. Principal... More

Hotel only $113

5 Hyatt Place Des Moines Downtown

4 stars
4.4 / 5 25 reviews

418 6th Ave. Map

Save 15% on your stay

Guest rooms feature contemporary decor with stylish furnishings including the Hyatt Grand beds, state-of-the-art media and work center with a high-definition 42 inch flat panel television that easily integrates with laptops, a comfortable cozy corner L-shaped... More

Hotel only $116

6 Embassy Suites Hotel Des Moines Downtown

3 stars
4.0 / 5 47 reviews

101 East Locust Street Map

Free cooked-to-order breakfast, Evening Reception

Downtown Des Moines hotel offers all-suites accommodations on RiverwalkThe Embassy Suites Des Moines - On the River offers all-suite accommodations in downtown Des Moines near the capitol, the East Village and Court Avenue District. The hotel is on the Principal... More

Hotel only $104


3 stars
3.9 / 5 29 reviews

1050 6th Avenue Map

Downtown Des Moines hotel with free wireless, parking, airport shuttleThe Holiday Inn Des Moines Downtown Mercy Campus is located close to Mercy Medical Center and Wells Fargo Arena and Iowa Events Center. Welcome amenities include free parking, an airport shuttle service... More

Hotel only $84

8 Hampton Inn Des Moines-Airport

3 stars
4.1 / 5 34 reviews

5001 Fleur Drive Map

Includes parking for up to 7 nights

get ready to take off...welcome to the Hampton Inn Des Moines-Airport.Here at the Hampton Inn® hotel at the Des Moines-Airport, we strive to make your life easier. And that starts with our convenient location. We're directly across from the Des Moines Airport and just... More

Hotel only $139

9 Des Lux Hotel

4 stars
Not yet reviewed

800 Locust St Map

These are no ordinary accommodations The largest in Des Moines and among the most welcoming anywhere, many Des Lux rooms and suites indulge with fireplaces and whirlpools. From our King Executive Rooms to the lavishly appointed Presidential Suite you will enjoy an array... More

Hotel only $129

10 Renaissance Des Moines Savery Hotel

4 stars
4.2 / 5 26 reviews

401 Locust Street Map

Rate includes breakfast

Elegant, historic skywalk hotel welcomes famous and non-famous alikeThe elegant Renaissance Des Moines Savery Hotel has hosted presidents and is listed on the National Register of Historic Places. A classy lobby with a chandelier welcomes famous and non-famous guests. Its... More

Sign up to receive our best deals

Get insider access to our best hotel deals, coupons and more!