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Santa Cruz Island Vacations

Your trip

Hotel options

Hotel stay must be within date range of Leave and Return.

Room 1
Age categories
Ages of children at time of trip (for pricing, discounts)

Your Santa Cruz Island vacation

From family vacations to last-minute romantic getaways, make Orbitz your first and only stop for Santa Cruz Island vacations. You can customize your trip with flights, hotels and activities to match your travel plans and tastes. Sweeten the pot with extra savings when you book your flight and hotel together.

Create your own Santa Cruz Island travel plans
Build your own Santa Cruz Island vacation itinerary. Choose a flight that matches your schedule and a hotel with the amenities you need. Book them together for extra discounts you won't find when booking separately.

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Reach out to an Orbitz travel specialist for Santa Cruz Island vacation assistance. Our specialists are available around the clock at 1-800-504-3248. We can even help with last-minute Santa Cruz Island vacations.

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Scope out your Santa Cruz Island vacation options and savings
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Santa Cruz Island Vacation Packages

Hotel only $268

1 Hotel Solymar

4 stars
Not yet reviewed

Charles Darwin and Thomas de Berlanga Map


We are located in the heart of the touristic district in Puerto Ayora. A variety of restaurants, bars and artisanal markets are nearby. The attractions nearby, include Galapagos National Park, Charles Darwin Research Station, Las Grietas, Tortuga Bay Beach and El... More

Hotel only $115

2 Red Mangrove Aventura Lodge

4 stars
Not yet reviewed


14 guest rooms divided in 2 areas, seaside, or inside the mangrove, all equipped with a/c, cable tv, private bathroom and hot water.Sea side restaurant with choice of Japanese or Galapagos fusion cuisine offers you the best choice in town. More

Hotel only $69

3 Red Mangrove Santa Cruz Divers

3 stars
Not yet reviewed


We have 9 rooms; several of them stand out from volcanic rock details of the islands.In the cafeteria you can enjoy a delicious American breakfast. Lunch and dinner are not offered on the property but will be provided at the Red Mangrove Aventura Lodge More

4 Villa Laguna Hotel

2 stars
Not yet reviewed

Moises Brito and Juan Montalvo Map

Villa Laguna is a shining example of comfort, located at Puerto Ayora on Santa Cruz Island. The hotel is three stories set in front of a fresh-water pool. Enjoy the El Manglar Restaurant, on site and eager for the opportunity to serve you breakfast, lunch, and dinner, at... More

5 Mainao Hotel

2 stars
Not yet reviewed

Matazarnos street and Indefatigable Map

Mainao Hotel is a pleasant and clean hotel with a friendly, experienced staff. Located near the main street of Puerto Ayora, it is conveniently accessible while being set apart from the busy activity of the town. Mainao has lovely outdoor open areas within the hotel to... More

6 Red Booby Hotel

2 stars
3.5 / 5 2 reviews

Plazas Avenue and Charles Binford Map

Your stay will be in a cozy environment like being at home, with a warm atmosphere of a great Hotel. Red Booby Hotel is located in the Center of Puerto Ayora city Santa Cruz Island, 5 minutes from the Malecon, located in Plazas Avenue and Charles Binford Street. The... More

Hotel only $200

7 Royal Palm Hotel - Galapagos

5 stars
5.0 / 5 1 reviews

Km18. Via Puerto Ayora-Baltra Map

The Royal Palm is a secluded hideaway nestling in the lush Miconia Highland Forests of Santa Cruz in the heart of the Galapagos. Combining elegant Colonial style with traditional island design, this is as close to nature as luxury will allow. Set in its own 150 hectare... More