South San Francisco hotels

Room 1
*Ages of children at time of trip (for pricing, discounts)

What travelers to South San Francisco are saying

We only stayed one night and had dinner a few blocks away. The hotel was a little difficult to find, since there was a regular airport road and a s. airport road that was on the other side of the freeway. But...we made it. Don't know much else about S. San Fran. The restaurant we went to for dinner was excellent.
Brigitte K. Jul 15, 2015
The room was very clean. The large courtyard garden was pretty and well maintained. Employees were courteous and helpful. Airport shuttle was on time and the driver was very nice. The hotel is practical and functional optional. It is clean which is a key priority when looking for an economical option for stay.
Jojo H. Apr 29, 2015
Honestly all the SSF is useful for is a launch point to San Francisco. There are a lot of hotels here because of the proximity to the airport. The nice thing is that the hotels are significantly cheaper than downtown San Francisco and you can get on the BART to get to the city within 20 minutes.
Alvaro G. May 15, 2015


Earn up to 5% on hotels and 1% on flights - It's free!

By clicking, I agree to the terms and conditions.

South San Francisco Hotels

Orbitz makes it easy to find the best South San Francisco hotel deals for your trip. With an outstanding selection, easy-to-use search tools and descriptive hotel profiles, you'll find South San Francisco hotel deals in a wink..

Great selection of hotels in South San Francisco

Whether you're searching for hotels in South San Francisco on business, or hunting for a family getaway, South San Francisco hotel options are only a click away. Find hotels in South San Francisco with the location, star-rating and facilities you need. Narrow your search results even further by star rating, hotel chain and amenities, such as free parking, babysitting services, or fitness centers. And with area maps, you can view South San Francisco hotels close you are to the airport and nearby attractions.

South San Francisco hotel reviews, photos and virtual tours

Thanks to photos and virtual tours, you can look before you book your South San Francisco hotel reservation. Check out South San Francisco hotel properties using interactive tools which allow you view hotel rooms, common areas and key features. On Orbitz, you can also learn more about hotels in South San Francisco with unbiased reviews from verified South San Francisco hotel guests. We ask guests to offer candid feedback on services, comfort, location, value and amenities.

Grab South San Francisco hotel deals and special offers

Orbitz works around the clock to find exclusive offers and South San Francisco hotel deals, just for you. Sign up for deals by e-mail where you'll get first crack at money-saving extras like promo codes, resort credits, free nights and more. You can also "Like" Orbitz on Facebook and follow us on Twitter to receive up-to-the-minute news on hotel discounts, giveaways and more.

24/7 support with South San Francisco hotel reservations

When it comes to finding hotels in South San Francisco, an Orbitz specialist can help you find the property right for you. Chat live or call 1-800-454-3743 any time for help booking your hotels in South San Francisco. Our team of experts can help you pinpoint South San Francisco hotels options suited to your tastes and budget.

Forget Orbitz change or cancel fees on South San Francisco hotels

On Orbitz, South San Francisco hotel deals mean flexibility. If you need to change your South San Francisco hotel reservations, or cancel your stay, Orbitz doesn't charge cancel or change fees. Orbitz also offers great selection on airline tickets, vacation packages, and car rental deals to so you can plan your trip to South San Francisco all in one place.


Recently Rated South San Francisco Hotels

Hotel Reviews Stars Price from
CitiGarden Hotel
3.1 / 5
263 reviews
2 stars $114
Courtyard by Marriott San Francisco Airport/Oyster Point Waterfront
3.8 / 5
48 reviews
3 stars $151
Inn at Oyster Point
4.4 / 5
30 reviews
3 stars $178
BEST WESTERN PLUS Grosvenor Airport Hotel
3.4 / 5
223 reviews
3 stars $125
Embassy Suites San Francisco Airport - South San Francisco San Francisco
3.6 / 5
36 reviews
4 stars $170
La Quinta Inn San Francisco Airport North
3.1 / 5
110 reviews
2 stars $113
Quality Inn & Suites
3.8 / 5
21 reviews
2 stars $135
Americas Best Value Inn
3.8 / 5
24 reviews
2 stars $180
Larkspur Landing South San Francisco
4.1 / 5
67 reviews
3 stars $153
Comfort Inn & Suites San Francisco Airport North
3.6 / 5
181 reviews
2 stars $98

Activities in South San Francisco

San FrancisGO Pass

This valuable San Francisco package includes the 48 hours Hop-on Hop-off Downtown Loop as well as a choice of 2 additional popular tours and attractions of San Francisco!

California Academy of Sciences

Explore earth, ocean and space - all in one place by visiting the 'Greenest Museum' in the World. Named by Conde Nast Traveler one of the 'New Wonders of the World', the California Academy of Sciences is the only place on the planet to combine an aquarium, natural history museum, World's largest all-digital planetarium and four story rainforest under a 2.5 acre living roof.

Combo: Muir Wood & Sausalito With Bay Cruise

Take time out from San Francisco on a half-day trip to Muir Woods and Sausalito. This enthralling half-day trip takes you across the Golden Gate Bridge to the Bay Area's most popular national monument and the prettiest village in California.

Combo: San Francisco City Tour with Bay Cruise

Now Crosses the Golden Gate Bridge!
Enjoy a four-hour guided tour of San Francisco. At each stop, you’ll have the chance to get off the bus and see the Super Sights. Along the way, your fully narrated tour will show you San Francisco like you’ve never seen it before!

Bus and Boat: 48 Hour Hop-On Hop-Off + Bay Cruise

The one hour San Francisco Bay Cruise takes you out towards the Golden Gate Bridge from Fisherman's Wharf. En route we pass Fort Mason, the Marina district, St. Francis Yacht Club and the Presidio. Also, see the best that San Francisco has to offer all at your own pace with this 48 hour ticket!  

Featured South San Francisco Hotels

From $125

1 BEST WESTERN PLUS Grosvenor Airport Hotel

3 stars
3.4 / 5 223 reviews

380 South Airport Blvd

Save 30%

Located at SFO, offering complimentary shuttle service,full hot breakfast buffett offered at a nominal charge, over night parking is $7.00 per day. The Best Western Grosvenor San Francisco luxury...

Good for one night
It took forever to get our room ready for us, but it was a nice one night stay.
Aug 29, 2015
From $114

2 CitiGarden Hotel

2 stars
3.1 / 5 263 reviews

245 South Airport Blvd.

The CitiGarden Hotel San Francisco International Airport North is located just 5 minutes from the airport and offers complimentary 4:00am to 12:00 O'clock midnight airport shuttle. The hotel...

good place to layover
the location is not good for taking a walk to see the area, but works great as a place to spend a long layover at SFO.
Aug 22, 2015
From $135


3 stars
3.3 / 5 74 reviews

275 South Airport Blvd.

The Holiday Inn San Francisco International Airport is located in the birthplace of Biotech and ideally situated for travelers. We are adjacent to the South San Francisco Conference Center, just...

Best location and value for money
Close proximity to airport, convenient access to 101
May 19, 2015
From $170

4 Embassy Suites San Francisco Airport - South San Francisco San Francisco

4 stars
3.6 / 5 36 reviews

250 Gateway Boulevard

7 Day Stay & Fly

The Embassy Suites San Francisco Airport – South San Francisco hotel is conveniently located 10 miles south of downtown San Francisco and 3 miles from San Francisco Airport (SFO). This San...

It's good
It's good overall the staff are friendly there is just one problem with this hotel which is that the check out at 12 and bell guys take break in the same time. That really annoying when you want to...
Aug 26, 2015
From $98

5 Comfort Inn & Suites San Francisco Airport North

2 stars
3.6 / 5 181 reviews

121 E. Grand Ave.

FREE transportation to and from San Francisco International Airport. Free continental breakfast from 6-9:30 a.m. Mon-Fri, and from 6:30-10 a.m. Sat-Sun. Local restaurant menus with free delivery...

One night stay before departure
Beautiful courtyard with hot tub to relax, nice cleanerooms. Free convenient on time shuttle to airport. Would recommend staying for airport departure.
Aug 31, 2015
From $113

6 Ramada Limited San Francisco Airport North

3 stars
3.4 / 5 115 reviews

721 Airport Blvd

Stay 2, Save 15%

The Ramada Limited San Francisco Airport North is conveniently located 4 miles north of San Francisco International Airport and 8 miles south of downtown San Francisco. We provide exceptional...

good for short stay near the airport
overall, the room and stuff was great -- they even have a local pizza joint who delivers to your room until like 3 AM... my only complaint was that the front desk staff was not the sharpest crayons...
Jul 16, 2015
From $178

7 Inn at Oyster Point

3 stars
4.4 / 5 30 reviews

425 Marina Blvd.

Newly renovated boutique style Inn located on the San Francisco Bay approximately two miles north of the San Francisco Airport. Expansive guestrooms feature triple sheeted comfort beds, fireplaces,...

San Francisco Prize
The Inn was lovely, clean with many surpise amenities, bathrobes, free continental breakfast, spacious, and fine toilletries. Car service to and from train excellent. The best. The Inn is quite...
Jul 16, 2015
From $135

8 Hilton Garden Inn San Francisco Airport North

3 stars
4.1 / 5 65 reviews

670 Gateway Blvd

Complimentary wired and Wi-Fi Internet Access

The Hilton Garden Inn San Francisco Airport North hotel is located in California's South San Francisco, an area that many Biotech Companies call home. Our neighbors include: Genentech, SAP, Amgen,...

Everything was great. Very easy check in. Room was very clean. Staff were so nice and very accommodating! I will defiantly be staying here again!
Jun 13, 2015
From $113

9 La Quinta Inn San Francisco Airport North

2 stars
3.1 / 5 110 reviews

20 Airport Blvd

Flat-panel TVs with 30 channels of HD programming. Easy-access Plug-and-Play feature makes it simple to connect electronics. 100% Non Smoking Hotel The La Quinta Inn San Francisco Airport North...

Friendly staff..clean room..would definitely recommend
Aug 28, 2015
From $120

10 Hotel Focus SFO

2 stars
2.7 / 5 3 reviews

111 Mitchell Avenue

This South San Francisco inn is a 10 minute drive from San Francisco International Airport. Continental breakfast is provided and rooms feature satellite TV with HBO. A sitting area and a work desk...

Okay stay
Nice place to just rest/sleep. Great location if you have a car. No immediate neighboring restaurants. Great friendly staff.
Jul 21, 2015
From $153

11 Larkspur Landing South San Francisco

3 stars
4.1 / 5 67 reviews

690 Gateway Boulevard

Save 10% on your stay

Larkspur Landing is a completely new hotel concept specifically developed and designed to satisfy the needs of upscale business and leisure travelers seeking all the warm comforts of home while...

Decent place with kitchen
Gym facilities are pretty small but overall a nice place to stay with kitchen and laundry
Jul 25, 2015
From $125

12 Four Points by Sheraton Hotel & Suites San Francisco Airport

3 stars
3.6 / 5 23 reviews

264 South Airport Boulevard

Save 30% on your stay

Prime Location. The Four Points by Sheraton Hotel & Suites San Francisco Airport provides easy access to everything in the Bay Area. We are conveniently located near Highway 101, only 1.5 miles...

Great Place for NYE
Got this room to be a location hub for our NYE festivities. I was very pleasantly surprise by the size of the room which is two floor with the master bedroom upstairs. We were able to host a...
May 16, 2015
From $160

13 Americas Best Value Inn

2 stars
3.8 / 5 24 reviews

701 Airport Blvd

Welcome to Americas Best Value Inn and Suites - San Francisco Airport North. We are conveniently located off Highway 101/ only three miles north from San Francisco International Airport and eight...

Pre-flight lodging
Good place to stay before flying out in the morning. Adequate and clean.
Aug 27, 2015
From $85

14 Days Inn San Francisco South/Oyster Point Airport

2 stars
2.6 / 5 22 reviews

1113 Airport Blvd

Stay 2, Save 15%

The Days Inn San Francisco Airport is conveniently located 3.5 miles north of San Francisco International Airport and 8 miles south of downtown San Francisco. We provide exceptional customer...

Ok hotel
The stay was was alright. For the price could have been better but all the other places r even more expensive. Good for just a night or two
Jun 26, 2015
From $151

15 Courtyard by Marriott San Francisco Airport/Oyster Point Waterfront

3 stars
3.8 / 5 48 reviews


Rate includes breakfast

Courtyard San Francisco Airport/Oyster Point Waterfront makes life on the road comfortable and convenient. As one of the premier hotels in South San Francisco, we offer complimentary shuttle...

comfortable place to sleep, good location to get in and out of city
it was fine. We've stayed there before and were happy to come back. We visit friends and family and go into SF City each day. We learned to use the Cal train to conveniently go to AT & T park. we...
Aug 18, 2015
From $135

16 Quality Inn & Suites

2 stars
3.8 / 5 21 reviews

410 S. Airport Blvd.

Close to Airport. FREE high speed internet service (DSL). 100% of rooms are non smoking. FREE shuttle to and from San Francisco International Airport (4am-midnight). Parking fee 6.00 usd per night...

A Good Value for Money
The rates in San Franciso during this time were all quite high and the Quality Inn and Suites was at the lower end of the spectrum but quite close to the airport. Surprisingly, the room was clean,...
Jul 30, 2015
From $146

17 Hampton Inn San Francisco-Airport

2 stars
3.9 / 5 35 reviews

300 Gateway Blvd.

Free On The House hot breakfast, Wi-Fi

prepare to be pampered in San Francisco...welcome to the Hampton Inn San Francisco-Airport.From the majestic Golden Gate Bridge to the bustling Fisherman's Wharf, from the exotic atmosphere of...

i love to stay . i also like the location . servcice is also good . breakfast is also very good.
May 19, 2015
From $200

Step into the relaxing style of Residence Inn San Francisco Airport/Oyster Point Waterfront. Renovated in 2014, our extended-stay hotel in San Francisco offers a refreshing escape on the Bay just 9...

san fran trip
we had a great time & this hotel was the best with service & being helpful
Jan 5, 2015
From $148


3 stars
3.8 / 5 101 reviews

373 South Airport Blvd.

Contemporary San Francisco Airport Hotel within minutes from Downtown San Francisco. The newly renovated Holiday Inn Express San Francisco Airport North is centrally located just one mile north of...

single night
I Really enjoyed my stay at the Holiday Inn. It was a great value. The hotel receptionist was very friendly and accommodating. As soon as i settled in my room she called me to ask if I was...
Feb 11, 2015