Welcome to the Holiday Inn Express Hotel & Suites Cape Girardeau. This newly built Cape Girardeau hotel opened in June 2005. Conveniently located at Interstate 55 and William St. (exit 96). The hotel is just minutes from Southeast Missouri State University, St. Francis Hospital, Southeast Missouri State Hospital, Doctors Park, Show Me Center, Procter & Gamble, Nordenia, Shawnee Park and Biokyowa. The Holiday Inn Express & Suites Cape Girardeau Hotel is midway between Memphis and St. Louis on I-55 within the Park West Hospitality Center Complex. Surrounded by a wide selection of eating establishments, this new hotel features 102 one room suites, a grand lobby area, free high speed internet service and two meeting rooms. Hotel amenities include an indoor pool, whirlpool, fitness room, game room and refrigerator & microwave in every room. We are proud to be a 100% smoke free facility. When selecting a Cape Girardeau hotel, stay SMART at the Holiday Inn Express Hotel & Suites. This hotel is committed to providing accessible facilities under the American Disabilities Act. If your accessibility needs are not met, please contact the Hotel Manager on Duty. Should you require additional information regarding accessible facilities for guests with disabilities, please call 1-800-Holiday (U.S. and Canada) or contact the hotel directly. For the hearing impaired, TDD service is available at 1-800-238-5544 within the U.S. and Canada.