By clicking, I agree to the terms

San Diego to Cape Girardeau Flights

Flight only Hotel only Flight + Hotel

Flight type

Round-trip One-way
Age of children at time of trip

We will search for applicable airfare discounts. Must have 1 adult for each infant in lap

San Diego and Cape Girardeau airports and terminals

Airports in San Diego CA, US
map of airports in San Diego
  • 1

    San Diego Airport (SAN)

    Distance from City Center: 2 miles

Back to menu Return to top

Airports in Cape Girardeau MO, US
map of airports in Cape Girardeau
  • 1

    Williamson County (MWA)

    Distance from City Center: 42.6 miles

  • 2

    Cape Girardeau Airport (CGI)

    Distance from City Center: 5.3 miles

  • 3

    Barkley Regional (PAH)

    Distance from City Center: 46.1 miles

Back to menu Return to top

Cheap flights from San Diego to Cape Girardeau

Sun Mon Tue Wed Thu Fri Sat
1 2 3 4 5 6
7 8 9 10 11 12 13
14 15 16 17 18 19 20
21 22 23 24 25 26 27
28 29 30 31

Highlighted price = Cheapest round-trip flights

Prices are round trip per person (conditions apply)

Featured Cape Girardeau Airport Hotels

Hotel only $93

Candlewood Suites CAPE GIRARDEAU

2 stars
4.3 / 5 7 reviews

485 South Mt. Auburn Road Map

Experience Historic Cape Girardeau from Hotel's Suites A historic college town in southeastern Missouri, Cape Girardeau is bordered on the east by the mighty Mississippi River.... More

Hotel only $112

Holiday Inn Express & Suites CAPE GIRARDEAU I-55

3 stars
4.5 / 5 19 reviews

3253 William Street Map

Welcome to Our Cape Girardeau Hotel.... More

Hotel only $81

Auburn Place Hotel and Suites

2 stars
4.4 / 5 11 reviews

3265 William St. Map

Free breakfast with over 25 items, indoor heated pool, large whirlpool, free high speed wireless internet in every room, located right off of I-55, microwaves and refrigerators in every room, and... More

Hotel only $119

Hampton Inn Cape Girardeau

3 stars
3.0 / 5 1 reviews

103 Cape West Parkway Map

Free On The HouseT hot breakfast, Wi-Fi

escape to the cape...welcome to the Hampton Inn Cape Girardeau.... More

Hotel only $89

Drury Lodge Cape Girardeau

3 stars
3.9 / 5 31 reviews

104 South Vantage Drive Map

The Extras Aren't Extra at Drury Hotels. Your great rate includes FREE hot food and cold beverages at our 5:30 Kickback. FREE hot breakfast, FREE wireless Internet access and FREE long distance.... More

Hotel only $69

Pear Tree Inn Cape Girardeau

2 stars
3.7 / 5 38 reviews

3248 William Street Map

The Extras Aren't Extra! Your great rate includes FREE evening snacks and beverages. FREE breakfast, FREE wireless Internet access and FREE long distance. Don't miss our great breakfast buffet. ... More

San Diego to Cape Girardeau Intro 49

When you’re ready to take your next trip, get the most affordable prices on flights from San Diego to Cape Girardeau with Orbitz! The guaranteed low prices and cutting-edge mobile tools on Orbits make it easy for you to plan your next great vacation.

Keep Up With Sudden Flight Changes

As any traveler knows, air travel can suddenly be temporarily halted due to service disruptions. Along with offering the best fares for flights from San Diego to Cape Girardeau, Orbitz also offers free mobile phone and email alerts that help you keep up with sudden changes to your flight plans. Choose from email, text, or voice message alerts.

Get Great Prices for San Diego to Cape Girardeau Flights

Orbitz features both an Android app and an iPhone app to give you the lowest prices for San Diego to Cape Girardeau flights. Use these mobile apps to get updates on your flight, the details of your itinerary, and to learn about available hotel deals in the area.

Fly for Less and Earn Miles

Did you know you can earn miles and points for your frequent flyer program with Orbitz? To do this with specific flights from San Diego to Cape Girardeau, enter your frequent flyer account number when you book your ticket online. For even more convenience, keep a record of your loyalty travel program numbers directly with Orbitz by storing them in your account profile. This way, you can add your account numbers to your next reservation for San Diego to Cape Girardeau flights automatically without the annoying hassle of having to look them up.