By clicking, I agree to the terms

Detroit to Florence Flights

Flight only Hotel only Flight + Hotel

Flight type

Round-trip One-way
Age of children at time of trip

We will search for applicable airfare discounts. Must have 1 adult for each infant in lap

Selected fares from Detroit to Florence

Departure Arrival Travel dates Round-trip
DTT FLO Wed, Dec 17 - Thu, Dec 18 $217
DTT FLO Wed, Dec 17 - Thu, Dec 18 $290
DTT FLO Wed, Dec 17 - Thu, Dec 18 $303
DTT FLO Wed, Nov 5 - Mon, Nov 10 $1,109

Detroit and Florence airports and terminals

Airports in Detroit MI, US
map of airports in Detroit
  • 1

    Detroit Wayne County Airport (DTW)

    Distance from City Center: 17.5 miles

  • 2

    Willow Run (YIP)

    Distance from City Center: 26 miles

Back to menu Return to top

Airports in Florence SC, US
map of airports in Florence
  • 1

    Florence Airport (FLO)

    Distance from City Center: 3.2 miles

Back to menu Return to top

Cheap flights from Detroit to Florence

Sun Mon Tue Wed Thu Fri Sat
1
2 3 4 5
$424
6 7 8
9 10 11 12 13 14 15
16 17 18 19 20 21 22
23 24 25 26 27 28 29
30

Highlighted price = Cheapest round-trip flights

Prices are round trip per person (conditions apply)

Featured Florence Airport Hotels

Hotel only $62

Ramada Florence Center

2 stars
2.5 / 5 33 reviews

1819 West Lucas Street Map

Stay 3, Save 20%

Refresh at this Ramada Florence Center hotel conveniently located off Interstate 95 near Florence Regional Airport, NASCAR races at Darlington Raceway, NASCAR Stock Car Museum, Florence Civic... More

Hotel only $55

Baymont Inn & Suites Florence

2 stars
3.5 / 5 33 reviews

1826 West Lucas Street Map

Stay 3, Save 20%

Enjoy the southern hospitality at this Baymont Inn and Suites Florence, just off Interstate 95 and minutes from the Florence Regional Airport, many corporate offices, the Florence Civic Center,... More

Hotel only $48

Suburban Extended Stay Hotel

2 stars
3.0 / 5 67 reviews

1914 West Lucas Street I-95 & US 52 Map

When you stay at a Suburban Extended Stay Hotel, you can rest assured that you're getting a good deal. You will have your own in-room kitchen, on site laundry, FREE cable TV, and Internet/data... More

Hotel only $80

La Quinta Inn & Suites Florence

3 stars
3.4 / 5 22 reviews

2123 West Lucas Street Map

...Conveniently located right off I-95 just minutes from the Florence Regional Airport, and Darlington Raceway/Museum.... More

Hotel only $64

Red Roof Inn Florence Civic Center

2 stars
3.4 / 5 41 reviews

2690 David McLeod Blvd Map

Magnolia Mall, with 70 great stores, is right across the street. We are adjacent to the Florence City-County Civic Center; Darlington International Raceway is just 12 miles and North Carolina... More

Hotel only $100

Holiday Inn Express & Suites FLORENCE I-95 & I-20 CIVIC CTR

3 stars
4.4 / 5 17 reviews

3440 West Radio Drive Map

Experience Top-Rated Service at Our Florence, SC Hotel Centrally located between Florida and New York in the heart of Florence, South Carolina, this hotel is at the intersection of I-95 and I-20... More

November

Lowest roundtrip airfare in November from Detroit to Florence

Travel dates Departure Arrival Stops: Round-trip
Leave Wed, Nov 5 Detroit (DTW) Florence (FLO) US Airways $424
Earn $4.24
Return Mon, Nov 10 Florence (FLO) Detroit (DTW) US Airways
Back to menu Return to top

December

Lowest roundtrip airfare in December from Detroit to Florence

Travel dates Departure Arrival Stops: Round-trip
Leave Wed, Dec 17 Detroit (DTW) Florence (FLO) US Airways $217
Earn $2.17
Return Thu, Dec 18 Florence (FLO) Detroit (DTW) US Airways
Back to menu Return to top

Detroit to Florence Intro 12

Grab great fares on Detroit to Florence flights with Orbitz, your #1 source for discount international and domestic air tickets. Our cutting-edge mobile tools and great online search functionality make booking your next budget trip a breeze.

Mobile Apps for Exclusive Deals on Flights From Detroit to Florence

You don’t have to sit down at a computer to find the latest flight bargains. Orbitz offers a mobile app for Android, iPhone, and tablet devices, which will keep you alert to fantastic fares, hotel discounts, and more great savings. The app gives you real-time low fares for flights from Detroit to Florence and lets you book your hotel room with a few simple clicks.

Find Your Detroit to Florence Flights, Car, and Hotel in One Place

Orbitz gives you the latest deals on air fares, hotels, cruises, and car rentals at up to 50% off. Booking your flights from Detroit to Florence is easy whether you are using a computer, with the Orbitz mobile app, or through m.orbitz.com on your mobile device’s Web browser.

Stay Informed on Your Trip

Orbitz sends you alerts about the latest updates to your Detroit to Florence flights, such as delays. Receive the updates via your email or mobile phone. Use the Orbitz app to stay updated on your flight status and baggage claim details.

Earn Miles for Flights From Detroit to Florence

On qualified flights, add your frequent flyer number to your booking to get miles or points for your trip.