join Orbitz Rewards

By clicking, I agree to the terms

Des Moines to Knoxville Flights

Age of children at time of trip

We will search for applicable airfare discounts. Must have 1 adult for each infant in lap

Selected fares from Des Moines to Knoxville

Departure Arrival Travel dates Round-trip
DSM TYS Sat, Mar 14 - Mon, Mar 16 $477
DSM TYS Sat, Mar 14 - Mon, Mar 16 $588
DSM TYS Fri, Sep 18 - Sun, Sep 20 $716

Des Moines and Knoxville airports and terminals

Airports in Des Moines IA, US
map of airports in Des Moines
  • 1

    Des Moines Airport (DSM)

    Distance from City Center: 5.5 miles

Back to menu Return to top

Airports in Knoxville TN, US
map of airports in Knoxville
  • 1

    Knoxville Airport (TYS)

    Distance from City Center: 11.2 miles

Back to menu Return to top
Sun Mon Tue Wed Thu Fri Sat
1 2 3
4 5 6 7 8 9 10
11 12 13 14 15 16 17
18 19 20 21 22 23 24
25 26 27 28 29 30 31

Highlighted price = Cheapest round-trip flights

Prices are round trip per person (conditions apply)

Featured Knoxville Airport Hotels

Hotel only $109

Hilton Knoxville Airport

3 stars
4.5 / 5 21 reviews

2001 Alcoa Highway Map

Includes parking for up to 7 nights

The Hilton Knoxville Airport hotel in Alcoa, Tennessee is connected to McGhee Tyson airport by a covered walkway and is a convenient place to stay whatever your reason for visiting Knoxville.... More

Hotel only $79

La Quinta Inn & Suites Knoxville Airport

3 stars
4.2 / 5 16 reviews

126 Cusick Rd Map

Welcome to the newly remodeled La Quinta Inn & Suites Knoxville Airport hotel, located in the lovely city of Alcoa, rich in Tennessee history.... More

Hotel only $85

Courtyard by Marriott Knoxville Airport Alcoa

3 stars
3.8 / 5 6 reviews

141 Furrow Way Map

Rate includes breakfast

At Courtyard Knoxville Airport Alcoa, we offer comfort, convenience and style.... More

Hotel only $47

Americas Best Value Inn

2 stars
2.4 / 5 8 reviews

2450 Airport Highway Map

Holiday Sale - Save 20% on your stay

Welcome to Americas Best Value Inn Knoxville Airport/Alcoa; conveniently located just off of Highway 129 and minutes away from McGhee Tyson Airport.... More

Hotel only $79

Comfort Suites Airport

2 stars
3.9 / 5 10 reviews

140 Cusick Rd. Map

Located half mile from McGhee Tyson Airport, offering daily shuttle and Stay and Fly packages.... More

Hotel only $67

Country Inn & Suites By Carlson, Knoxville Airport, TN

3 stars
3.8 / 5 49 reviews

162 Cusick Road Map

Save 20% on your stay

...Knoxville airport hotel has free breakfast, Wi-Fi and airport shuttle.... More

March

Cheapest weekend flights in March from Des Moines to Knoxville

Travel dates Departure Arrival Stops: Round-trip
Leave Sat, Mar 14 Des Moines (DSM) Knoxville (TYS) US Airways $477
Earn $4.77
Return Mon, Mar 16 Knoxville (TYS) Des Moines (DSM) US Airways

Lowest roundtrip airfare in March from Des Moines to Knoxville

Travel dates Departure Arrival Stops: Round-trip
Leave Sat, Mar 14 Des Moines (DSM) Knoxville (TYS) US Airways $477
Earn $4.77
Return Mon, Mar 16 Knoxville (TYS) Des Moines (DSM) US Airways
Back to menu Return to top

Flights to Knoxville

Cheap Flights from Des Moines

Locating cheap flights from Des Moines is easy with the assistance of Orbitz.com. Des Moines International Airport (DSM) offers a wide range of affordable flights from top airline providers. This airport offers flights with United Airlines, Delta Airlines, Allegiant Airlines, US Airways and more. Des Moines International is located in Des Moines, IA at 5800 Fleur Drive and is approximately three miles from the downtown area of the city.

Airport Parking Information

DSM provides a variety of airport parking choices to its passengers. These choices include short-term, long-term and economy parking. Short-term rates start at $1per half-hour, with a $24-per-day maximum. Long-term rates start at $2 per hour, with a $12-per-day maximum. Economy rates at DSM start at $2 per hour, with a $5-per-day maximum.

DSM Transportation Information

Passenger transportation options include shuttle buses, car rentals, limousines, taxis and public transit. Bus transportation is offered by Greyhound, Jefferson Bus Lines and Trailways Bus System. Other options can be found through Alamo Car Rental, Budget Rent A Car, Capitol Cab Company and C & C Limousine Services, among others.

Restaurants at Des Moines International Airport

Travelers can choose from a variety of restaurants at DSM, many of which can be found at the Landside Food Court. This dining area is open from 4:30 am to 7:30 pm daily, and is home to a Pizza Hut Express and an American Grill restaurant, among others. Let Orbitz.com help you book cheap flights from Des Moines and learn about your airport options.

Knoxville Airport Information

Visitors coming to the Knoxville area usually fly into the McGhee Tyson Airport, just 14 miles south of the city. When you use Orbitz.com to book cheap flights to Knoxville, you will be able to choose from all of the major airlines that serve the airport, including Allegiant, American Airlines, Delta, Frontier, United and US Airways.

Ground Transportation in Knoxville

Knoxville doesn't offer much in the way of public transportation, but you will have your choice of shuttle vans, taxis and private car and limousine services to take you to your final destination. Orbitz.com can help you choose a rental car to get around while you are in the Knoxville area. You can also use Orbitz to book a hotel that offers free shuttle service to and from the airport.

Knoxville Area Weather Information

Knoxville winters can be chilly, with temperatures in the 20s, 30s and 40s, so make sure to pack a winter jacket or fleece to keep you warm. Summers are warm, with temperatures ranging from the high 60s to the high 80s. July usually sees the highest average rainfall, so be sure to pack a lightweight rain slicker or umbrella to keep you dry.

What to Do in Knoxville

Knoxville combines small-town Southern charm with the fun and activities you would expect to find in a big city. You can spend your time playing golf, visiting museums or touring some of the area's historical landmarks, but be sure not to miss the area's famous festivals and celebrations. Some of the city's most popular events include the Boomsday, Rossini and Dogwood Arts festivals and the Knoxville Brewers Jam. Enjoy your time in the city, and remember to use Orbitz.com the next time you want to book cheap flights to Knoxville.

Flight schedule for flights from Des Moines to Knoxville on Sat, Dec 27, 2014

Carrier Flight # Departing Arriving Aircraft Flight time
Airport Time Airport Time
American Airlines/US Airways AA3411/US3164 DSM 5:50 AM TYS 11:58 AM ER4/ERD 5hr 8min
US Airways/US Airways US6421/US3164 DSM 5:50 AM TYS 11:58 AM ER4/ERD 5hr 8min
US Airways/American Airlines US6421/AA3212 DSM 5:50 AM TYS 11:58 AM ER4/ERD 5hr 8min
American Airlines/American Airlines AA5546/AA5222 DSM 9:15 AM TYS 3:38 PM CR9/CRJ 5hr 23min
American Airlines/US Airways AA5546/US5222 DSM 9:15 AM TYS 3:38 PM CR9/CRJ 5hr 23min
US Airways/American Airlines US5546/AA5222 DSM 9:15 AM TYS 3:38 PM CR9/CRJ 5hr 23min
US Airways/US Airways US5546/US5222 DSM 9:15 AM TYS 3:38 PM CR9/CRJ 5hr 23min
Delta Air Lines/Delta Air Lines DL3319/DL3612 DSM 10:10 AM TYS 5:00 PM CRJ/CRJ 5hr 50min
American Airlines/American Airlines AA5478/AA4980 DSM 1:45 PM TYS 7:23 PM CR9/CRJ 4hr 38min
American Airlines/US Airways AA5478/US4980 DSM 1:45 PM TYS 7:23 PM CR9/CRJ 4hr 38min
US Airways/American Airlines US5478/AA4980 DSM 1:45 PM TYS 7:23 PM CR9/CRJ 4hr 38min
US Airways/US Airways US5478/US4980 DSM 1:45 PM TYS 7:23 PM CR9/CRJ 4hr 38min
American Airlines/American Airlines AA2849/AA3226 DSM 4:35 PM TYS 10:13 PM ER4/ER4 4hr 38min