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Des Moines to Florence Flights

Flight only Hotel only Flight + Hotel

Flight type

Round-trip One-way
Age of children at time of trip

We will search for applicable airfare discounts. Must have 1 adult for each infant in lap

Des Moines and Florence airports and terminals

Airports in Des Moines IA, US
map of airports in Des Moines
  • 1

    Des Moines Airport (DSM)

    Distance from City Center: 5.5 miles

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Airports in Florence SC, US
map of airports in Florence
  • 1

    Florence Airport (FLO)

    Distance from City Center: 3.2 miles

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Cheap flights from Des Moines to Florence

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Highlighted price = Cheapest round-trip flights

Prices are round trip per person (conditions apply)

Featured Florence Airport Hotels

Country Hearth Inn Florence

3 stars
2.1 / 5 12 reviews

831 South Irby Street Map

...Located next to downtown Florence - 5 minutes from the Bus Depot, 10 minutes from Amtrak Train Station, 10 minutes from Florence Regional Airport.... More

Hotel only $58

Ramada Florence Center

2 stars
2.5 / 5 33 reviews

1819 West Lucas Street Map

Stay 3, Save 20%

Refresh at this Ramada Florence Center hotel conveniently located off Interstate 95 near Florence Regional Airport, NASCAR races at Darlington Raceway, NASCAR Stock Car Museum, Florence Civic... More

Hotel only $55

Baymont Inn & Suites Florence

2 stars
3.5 / 5 33 reviews

1826 West Lucas Street Map

Stay 3, Save 20%

Enjoy the southern hospitality at this Baymont Inn and Suites Florence, just off Interstate 95 and minutes from the Florence Regional Airport, many corporate offices, the Florence Civic Center,... More

Hotel only $48

Suburban Extended Stay Hotel

2 stars
3.0 / 5 66 reviews

1914 West Lucas Street I-95 & US 52 Map

When you stay at a Suburban Extended Stay Hotel, you can rest assured that you're getting a good deal. You will have your own in-room kitchen, on site laundry, FREE cable TV, and Internet/data... More

Hotel only $79

La Quinta Inn & Suites Florence

3 stars
3.4 / 5 22 reviews

2123 West Lucas Street Map

...Conveniently located right off I-95 just minutes from the Florence Regional Airport, and Darlington Raceway/Museum.... More

Hotel only $64

Red Roof Inn Florence Civic Center

2 stars
3.4 / 5 40 reviews

2690 David McLeod Blvd Map

Magnolia Mall, with 70 great stores, is right across the street. We are adjacent to the Florence City-County Civic Center; Darlington International Raceway is just 12 miles and North Carolina... More

Des Moines to Florence Intro 35

Des Moines to Florence flights are offered at fantastic discount by Orbitz. Book air tickets now and cut those extra costs out of your travel budget to ensure a rewarding travel experience. With guaranteed low prices like these, can you afford to miss this discount?

Book cheap flights from Des Moines to Florence

Cheap airfares are available on flights from Des Moines to Florence. Use Orbitz to find the best flights that suit both your budget and the travel times that you need. Travelers who are looking for discounted rates on domestic or international flights need to look no further than Orbitz.

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As the world of technology rapidly expands around us, we are continuously finding new ways to improve our services, communications, and accessibility. With our cutting-edge mobile tools now available on Android, iPhone, and tablets, you can access detailed information on your bookings for flights from Des Moines to Florence at any time or anywhere. See your itinerary for your Des Moines to Florence flights, baggage and gate claim details, as well as hotel deals with our easy-to-use apps.

Get a great package with your Des Moines to Florence flights

With frequent updates on your flight status, including delays and changes in bookings, traveling becomes more hassle-free than ever. Not only do we offer huge discounted deals on flights from Des Moines to Florence, we also have fantastic savings on vacation packages, hotel room, cruises, activities, and car rentals so you can pick and choose and create the best travel package for you.