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Chicago to Florence Flights

Flight only Hotel only Flight + Hotel

Flight type

Round-trip One-way
Age of children at time of trip

We will search for applicable airfare discounts. Must have 1 adult for each infant in lap

Chicago and Florence airports and terminals

Airports in Chicago IL, US
map of airports in Chicago
  • 1

    Midway Airport (MDW)

    Distance from City Center: 9.5 miles

  • 2

    O'Hare Airport (ORD)

    Distance from City Center: 15.1 miles

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Airports in Florence SC, US
map of airports in Florence
  • 1

    Florence Airport (FLO)

    Distance from City Center: 3.2 miles

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Cheap flights from Chicago to Florence

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Highlighted price = Cheapest round-trip flights

Prices are round trip per person (conditions apply)

Featured Florence Airport Hotels

Hotel only $62

Ramada Florence Center

2 stars
2.5 / 5 33 reviews

1819 West Lucas Street Map

Stay 3, Save 20%

Refresh at this Ramada Florence Center hotel conveniently located off Interstate 95 near Florence Regional Airport, NASCAR races at Darlington Raceway, NASCAR Stock Car Museum, Florence Civic... More

Hotel only $55

Baymont Inn & Suites Florence

2 stars
3.5 / 5 33 reviews

1826 West Lucas Street Map

Stay 3, Save 20%

Enjoy the southern hospitality at this Baymont Inn and Suites Florence, just off Interstate 95 and minutes from the Florence Regional Airport, many corporate offices, the Florence Civic Center,... More

Hotel only $48

Suburban Extended Stay Hotel

2 stars
3.0 / 5 67 reviews

1914 West Lucas Street I-95 & US 52 Map

When you stay at a Suburban Extended Stay Hotel, you can rest assured that you're getting a good deal. You will have your own in-room kitchen, on site laundry, FREE cable TV, and Internet/data... More

Hotel only $80

La Quinta Inn & Suites Florence

3 stars
3.4 / 5 22 reviews

2123 West Lucas Street Map

...Conveniently located right off I-95 just minutes from the Florence Regional Airport, and Darlington Raceway/Museum.... More

Hotel only $64

Red Roof Inn Florence Civic Center

2 stars
3.4 / 5 41 reviews

2690 David McLeod Blvd Map

Magnolia Mall, with 70 great stores, is right across the street. We are adjacent to the Florence City-County Civic Center; Darlington International Raceway is just 12 miles and North Carolina... More

Hotel only $100

Holiday Inn Express & Suites FLORENCE I-95 & I-20 CIVIC CTR

3 stars
4.4 / 5 17 reviews

3440 West Radio Drive Map

Experience Top-Rated Service at Our Florence, SC Hotel Centrally located between Florida and New York in the heart of Florence, South Carolina, this hotel is at the intersection of I-95 and I-20... More

Chicago to Florence Intro 14

Orbitz combines guaranteed low prices with cutting-edge mobile tools for travel from Chicago to Florence to give you a travel experience that is second to none.

Bargain Travel at Your Fingertips

Orbitz provides the cheapest fares from Chicago to Florence. When reserving your flight you can mix and match a range of low cost airlines for you departing and returning domestic or international flights. This way you can travel on a budget while selecting the flights that suit your schedule.

Modern Tools for Fast-Paced Travel

Orbitz makes use of the latest technology to ensure that you are always kept up-to-date on the status of your Chicago to Florence flights. Through easy-to-use mobile Android and iPhone apps you can book low cost flights from Chicago to Florence and choose a range of cheap hotels to stay in.

Enjoy Stress-Free Travel with Flight Alerts

Once you have booked your flights from Chicago to Florence on Orbitz you will always be kept informed of any changes to your flight. When you opt into Orbitz’s free email and SMS alerts on your Chicago to Florence flights you can ask Orbitz to send the flight details to up to 6 other contacts, so keeping your family and business team informed is a cinch.

Frequent Flyer Program

For loyal Orbitz customers who fly from Chicago to Florence the chance to join our frequent flyer program is an added bonus. Simply log-on to your online account and input your frequent flyer number for future flights.