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  Home / Flights on American Airlines / American Airlines Flights from Des Moines (DSM) to St Louis (STL)

American Airlines Flights from Des Moines (DSM) to St Louis (STL)

Orbitz is pleased to offer airline tickets on American Airlines, which operates a daily non-stop flight from Des Moines (DSM) to St Louis (STL) regularly scheduled to depart at 7:20am and arrive at 8:25am, and 4 additional non-stop flights, departing between 10:45am and 5:20pm on select days of the week. Usually an Embraer RJ145 Amazon or Embraer RJ140 is flown for this route. The average travel time from Des Moines, IA to St Louis, MO is 1 hour and 6 minutes.

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Regularly Scheduled Flights to St Louis (STL) from Des Moines (DSM)
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During your St Louis vacation, don't miss these great establishments and attractions:

Missouri History Museum
St. Louis's history is presented through photographs, memorabilia, first-person narratives, portraits, and more, with displays featuring the city's role in westward expansion, the Dred Scott case (which upheld slavery), famous St. Louisans such as Chuck Berry and Tennessee Williams, the 1904 World's Fair held at Forest Park, a replica of Charles Lindbergh's Spirit of St. Louis plane and other items relating to his life and solo transatlantic flight, and exhibits of the city's past. Allow 1 hour.

Missouri Botanical Garden
Opened in 1859, this is the country's oldest and one of its best botanical gardens: a 79-acre delight featuring the nation's largest Japanese strolling garden, a Chinese garden, a geodesic-domed rainforest greenhouse, an 1882 brick conservatory housing camellias, a scented garden for the visually impaired, a sculpture garden with works by Carl Milles, a hedge maze, a home-gardening resource center, and themed gardens ranging from a Victorian garden to an English woodland garden. A must-see for gardeners, who can easily spend 2 or 3 hours of bliss here.

Anheuser-Busch Brewery
Anheuser-Busch, one of the world's largest beer brewers, was established at this site in the 1860s, and many architectural gems from that time period remain. Tours of the brewing process take in the 1885 Clydesdale stable, the historic 1892 Brew House, and the packaging plant, ending with free drinks. Allow 1 1/2 hours. Tours begin at 12th and Lynch streets (I-55 at Arsenal).


Make your reservations for discount hotel rooms in the St Louis area, including:

Drury Inn Union Station
Part of a St. Louis-based chain, this beautifully restored former YMCA, built in 1907, is across from Union Station and offers rooms with refrigerators, microwaves, and free popcorn and soda; free evening beverages and snacks (Mon-Thurs); free local calls; and many other perks (including laundry facilities), making this a great place for families. Note that some rooms face inward, meaning no views.

Omni Majestic Hotel
Built in 1914, this National Historic Landmark appeals to business travelers and celebrities alike with its old world charm, downtown location, complimentary downtown shuttle, excellent service, and fitness room. The comfortable rooms have more character than most and are equipped with triple-sheeted beds, refrigerators, free wi-fi connections, and bathrobes. The Get Fit rooms sport treadmills.

Sheraton St. Louis City Center Hotel & Suites
With a great location right next to a MetroLink Station and within walking distance of Union Station and Busch Stadium, this hotel occupies four floors of the renovated Edison Brothers warehouse, distinctive for a trompe l'oeil mural that draws its imagery from St. Louis landmarks and the 1904 World's Fair. Pluses include the in-house parking garage and the 10,000-square-foot sports bar and grill featuring 28 TV screens and live bands on weekends. Rooms are enormous, with standard rooms measuring 550 square feet. Otherwise, rooms are rather ordinary and even seem empty due to their huge size (many also face an inner atrium, making them dark as well) but are equipped with refrigerators.


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Note: An infant who turns 2 before or during travel requires a child's fare.

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Note: An infant who turns 2 before or during travel requires a child's fare.

Need help booking your trip?

Book online or call

1-800-504-3248 (toll free)

1

I have a promotion code.

What's this?

Enter your promotion code, then look for hotels marked with the icon Coupon.

Need help booking your trip?

Book online or call

1-800-504-3248 (toll free)